{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T04:02:05Z","timestamp":1793073725458,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pseudomyxoma peritonei (PMP) is a rare condition, often associated with a poor prognosis if left untreated. Cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC), have emerged as the preferred treatment for this condition. The aim of this study was to report 22\u2010year single centre outcomes for PMP following CRS and HIPEC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis of a prospectively maintained database (CALHN reference number: Q20160412) from 2002\u20132024 was conducted on all patients that underwent CRS and HIPEC for PMP at The Queen Elizabeth Hospital, Adelaide, South Australia (TQEH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred and twenty one CRS procedures were performed on 108 patients. Complete cytoreduction (CC0\u20101) was achieved in 85.9% cases. The overall median 3, 5 and 10\u2010year survival rate for patients with PMP managed at TQEH was 70%, 55% and 23%, respectively. Among those who underwent HIPEC alongside CRS, the median survival was 92\u2009months, with a 5\u2010year survival rate of 62%. Median RFS was 109\u2009months, with 61% 5\u2010year RFS and 54% 10\u2010year RFS. The 5\u2010year survival rates for low\u2010grade PMP and high\u2010grade PMP without signet cells was 64.0% and 30.0%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CRS and HIPEC is a safe and effective treatment for patients with PMP, demonstrating a 62% survival at 5\u2009years. High\u2010grade PMP histology and CEA\u2009\u2265\u20095 were independent predictors of worse OS. Our results demonstrate that comparable survival rates and recurrence free intervals to those reported by high\u2010volume centres can be achieved, reinforcing the potential for successful outcomes in lower\u2010volume settings while maintaining treatment quality and patient safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ans.70214","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T06:05:05Z","timestamp":1750399505000},"page":"2112-2122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Long\u2010Term Survival Following Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (\n                    <scp>HIPEC<\/scp>\n                    ) for Pseudomyxoma Peritonei: A 22\u2010Year Single Institution Experience"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6928-1582","authenticated-orcid":false,"given":"Harleen","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Surgery The University of Adelaide, The Queen Elizabeth Hospital  Woodville Australia"},{"name":"Adelaide Medical School The University of Adelaide  Adelaide Australia"},{"name":"Precision Cancer Medicine Theme South Australian Health and Medical Research Institute  Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita\u2010Chrissi","family":"Litinas","sequence":"additional","affiliation":[{"name":"Department of Surgery The University of Adelaide, The Queen Elizabeth Hospital  Woodville Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoper","family":"Lauder","sequence":"additional","affiliation":[{"name":"Department of Surgery The University of Adelaide, The Queen Elizabeth Hospital  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