{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:02:48Z","timestamp":1791514968256,"version":"4.3.4"},"reference-count":12,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2025,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Fiji currently uses a seven\u2010day Clarithromycin based triple therapy regimen for\n Heliobacter pylori<\/jats:italic>\n (\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n ) eradication, and the local eradication rate is unknown.\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n testing is performed using a rapid urease test (RUT) during gastroscopy in Fiji.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A year\u2010long prospective observational study was undertaken at the Colonial War Memorial Hospital in Fiji. Eligible participants included patients who had peptic ulcer disease (PUD) on gastroscopy and a positive RUT. Consenting participants were prescribed Clarithromycin based triple therapy for 7\u2009days, and underwent a second gastroscopy with RUT after 6 to 8\u2009weeks. Participants who tested positive on a repeat RUT received Clarithromycin based triple therapy for 14\u2009days, and underwent a third gastroscopy and RUT. Participants who remained positive for\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n were prescribed quadruple therapy for 14\u2009days.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Forty\u2010nine patients were enrolled in the study. Thirty\u2010six (73.5%) had a negative RUT after a seven\u2010day Clarithromycin\u2010based regimen. Eleven of the 13 participants who remained positive eradicated\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n after being given another course of the same regimen for 14\u2009days, resulting in a final eradication rate of 95.9%. The remaining two participants received quadruple therapy for 14\u2009days.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This study demonstrates an eradication rate of 73.5% using a seven\u2010day Clarithromycin\u2010based regimen in Fiji among\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n positive patients with PUD on gastroscopy. This was significantly improved using a 14\u2010day regimen.\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n has reduced susceptibility to the current seven\u2010day Clarithromycin based regimen. Future local guidelines should extend to 14\u2009days to achieve a greater eradication rate.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ans.70231","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T06:54:57Z","timestamp":1750661697000},"page":"1745-1749","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of \u2018Triple Therapy\u2019 in Eradicating Ulcer Related\n Helicobacter pylori<\/i>\n Infection at a Tertiary Hospital in Fiji\u2014A Pilot Study"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4895-6441","authenticated-orcid":false,"given":"Victa Vinay","family":"Kumar","sequence":"first","affiliation":[{"name":"Department in Internal Medicine Labasa Hospital Labasa Fiji"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4376-4118","authenticated-orcid":false,"given":"Claudia","family":"Paterson","sequence":"additional","affiliation":[{"name":"Department of Surgery, Te Whatu Ora \u2013 Counties Manukau University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8672-6379","authenticated-orcid":false,"given":"Andrew","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Surgery, Te Whatu Ora \u2013 Counties Manukau University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikash","family":"Sharma","sequence":"additional","affiliation":[{"name":"Faculty of Internal Medicine Fiji National University Suva Fiji"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1001110"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2016.12.001"},{"key":"e_1_2_9_4_1","volume-title":"Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 100B. A Review of Human Carcinogens","author":"IARC","year":"2012"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.07.007"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.563"},{"issue":"4","key":"e_1_2_9_7_1","first-page":"373","article-title":"First\u2010Line Therapies for \n Helicobacter pylori\n Eradication: A Critical Reappraisal of Updated Guidelines","volume":"30","author":"De Francesco V.","year":"2017","journal-title":"Annals of Gastroenterology"},{"key":"e_1_2_9_8_1","first-page":"205","volume-title":"Ministry of Health and Medical Services, Government of Fiji","author":"National Therapeutics and Drug Subcommittee","year":"2019"},{"key":"e_1_2_9_9_1","article-title":"Optimum Duration of Regimens for Helicobacter Pylori Eradication","volume":"12","author":"Yuan Y.","year":"2013","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_9_10_1","first-page":"11","article-title":"The Prevalence of Helicobacter Pylori Infection in Patients Undergoing Endoscopy at the Colonial War Memorial Hospital from January 2011 to January 2013. [Master's Thesis]","volume":"1","author":"Naidu R. N.","year":"2013","journal-title":"College of Medicine Nursing and Health Science"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1992.tb01487.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00168"},{"key":"e_1_2_9_13_1","unstructured":"\u201cHelicobacter pyloriInfection In: eTG complete [Internet]. Melbourne \u201d2016."}],"container-title":["ANZ Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.70231","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ans.70231","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.70231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:42:57Z","timestamp":1772970177000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.70231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,23]]},"references-count":12,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/ans.70231"],"URL":"https:\/\/doi.org\/10.1111\/ans.70231","archive":["Portico"],"relation":{},"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,23]]},"assertion":[{"value":"2025-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}