{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:46:29Z","timestamp":1793040389242,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2026,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n Despite neutropenia being considered a significant risk factor for acute perianal sepsis, there is a lack of consensus on treatment guidelines for perianal abscess in the immunocompromised patient, specifically in patients with neutropenia secondary to a haematological malignancy. The aim of the article is to review the available literature on. Whether surgical intervention produces better outcomes than a non\u2010surgical approach for perianal sepsis in the immunocompromised patient with a haematological malignancy.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Relevant papers were identified through electronic databases including PubMed, Medline and Scopus. Data were extracted independently by two authors on a Microsoft Excel spreadsheet up to July 2024.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of eight studies were included in the final analysis (124 cases). Perianal or rectal pain (\n n<\/jats:italic>\n \u2009=\u200981, 65.3%) was the most reported complaint, followed by fever (\n n<\/jats:italic>\n \u2009=\u200972, 58.1%), swelling and induration (\n n<\/jats:italic>\n \u2009=\u200954, 43.5%) and erythema was reported in 26 (21.0%) cases. The most common organisms cultured from blood and anorectum were\n \n Escherichia coli<\/jats:italic>\n <\/jats:styled-content>\n and\n \n Pseudomonas aeruginosa<\/jats:styled-content>\n .\n <\/jats:italic>\n A total of 12 deaths (18.8%) were reported out of the 64 patients who underwent conservative management, while 10 (16.7%) deaths were reported out of 60 patients who underwent surgical management. Complete wound healing or good wound granulation was achieved for 35 (54.7%) patients in the conservative group and 35 (58.3%) patients in the surgical group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Our review suggests that conservative management is an acceptable treatment in carefully selected patients without an obvious perianal abscess on cross\u2010sectional radiological imaging.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ans.70373","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T18:27:38Z","timestamp":1761762458000},"page":"751-758","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Management of Perianal Sepsis in Neutropenic Patients With Haematological Malignancies\u2014A Systematic Review"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6362-2187","authenticated-orcid":false,"given":"Thi Ai Van Terresa","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of General Surgery Concord Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6272-4640","authenticated-orcid":false,"given":"Zi Qin","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of General Surgery Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2019.01.036"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-013-1082-z"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.14740\/jh1251"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.931589"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-017-2785-7"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.15744"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-4-515"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02236900"},{"issue":"12","key":"e_1_2_11_10_1","first-page":"693","article-title":"Perianal Infections in Acute Leukemia","volume":"54","author":"Carlson G.","year":"1988","journal-title":"American Surgeon"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02049810"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piy081"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000324"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-016-0982-6"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2017.05.046"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.15141662"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-011-0298-y"}],"container-title":["ANZ Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.70373","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ans.70373","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.70373","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:40:07Z","timestamp":1777524007000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.70373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,29]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/ans.70373"],"URL":"https:\/\/doi.org\/10.1111\/ans.70373","archive":["Portico"],"relation":{},"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,29]]},"assertion":[{"value":"2025-01-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}