{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:26:17Z","timestamp":1782365177084,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The role of body composition, specifically sarcopenia and adiposity, in predicting chemotherapy toxicities and outcomes in non\u2010metastatic pancreatic cancer remains unclear. This review assesses the association between body composition metrics and chemotherapy\u2010related outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review of studies examining body composition via CT imaging in non\u2010metastatic pancreatic cancer patients undergoing chemotherapy was conducted. Six studies met inclusion criteria, evaluating sarcopenia in relation to chemotherapy toxicities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Two studies found a significant association between body composition indices and chemotherapy toxicities. There was no clear association with survival outcomes. No clear link with surgical complications was observed. Methodological variations, including chemotherapy regimens, sarcopenia definitions and body composition assessment techniques, contributed to heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This review highlights inconsistencies in body composition's role in predicting chemotherapy toxicities and outcomes in pancreatic cancer. Variability in study methodologies complicated comparisons. Standardising body composition analysis with attention to ethnic variations and treatment types is essential for refining personalised treatment strategies in pancreatic cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ans.70380","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T11:57:21Z","timestamp":1763121441000},"page":"394-402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Association Between Body Composition and Chemotherapy\u2010Induced Toxicity in Pancreatic Cancer: A Systematic Review"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3772-7516","authenticated-orcid":false,"given":"Xavier","family":"Morgan Schlicht","sequence":"first","affiliation":[{"name":"Department of Surgery Western Precinct, University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Otto","sequence":"additional","affiliation":[{"name":"Department of Surgery Western Precinct, University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Hutcheon","sequence":"additional","affiliation":[{"name":"Western Health Library Service, Western Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Surgery Western Precinct, University of Melbourne  Melbourne Victoria Australia"},{"name":"Department of Upper Gastrointestinal\/Hepatobiliary (HPB) Surgery Western Health  Melbourne Victoria Australia"},{"name":"General Surgery and Gastroenterology Institute, Epworth Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Western Health  Footscray Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7230-149X","authenticated-orcid":false,"given":"Justin","family":"Yeung","sequence":"additional","affiliation":[{"name":"Department of Surgery Western Precinct, University of Melbourne  Melbourne Victoria Australia"},{"name":"Department of Colorectal Surgery Western Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Pancreatic Cancer in Australia Statistics Canberra","author":"Cancer Australia","year":"2022"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26210"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-021-06648-1"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-016-0762-8"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2021.39.15_suppl.e16258"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1057631"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-023-01512-z"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.18812"},{"key":"e_1_2_10_10_1","volume-title":"Sarcopenia","author":"Ardeljan A. 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