{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T16:52:22Z","timestamp":1783788742844,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Acute Mesenteric Ischaemia (AMI) is a life\u2010threatening surgical emergency, with a high mortality rate. Timely revascularisation is crucial to avoid bowel necrosis; however, once tissue becomes non\u2010viable, surgical resection is necessary. Delineating viability is a critical challenge. Indocyanine Green (ICG) fluorescence, used to visualise tissue perfusion in elective resections, could be used to assess bowel perfusion in the emergency setting. This narrative synthesis aims to evaluate the benefit of intraoperative ICG in the context of AMI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review following PRISMA guidelines was conducted according to a predefined protocol (PROSPERO ID: 42024581088). The following electronic databases were interrogated between January 1st 1945 and 1st May 2024: EMBASE and Medline (via OVID). All studies that investigated the use of ICG in the management of AMI were considered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The search returned 2941 articles. 84 abstracts were reviewed leaving 6 articles with a total of 196 patients for full assessment and which were included in the final narrative synthesis. Macroscopic perfusion assessment was inconsistent with ICG in 35% of cases, with ICG proposing more conservative resection in 75%. No statistically significant difference in re\u2010look rates, morbidity or mortality was found when comparing ICG to visual assessment alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ICG may reduce length of bowel resection and both planned and unplanned re\u2010look laparotomies. Outcomes reporting is sparse and comparative studies lacking. Randomised studies comparing ICG against direct light are needed. Improved intraoperative decision\u2010making using ICG could optimise resection boundaries, enhance patient outcomes and reduce mortality in this critical population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ans.70433","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:00:40Z","timestamp":1767337240000},"page":"733-741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Investigating the Benefit of Fluorescence in Acute Mesenteric Ischaemia: A Systematic Review and Narrative Synthesis"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7761-5148","authenticated-orcid":false,"given":"Emily J.","family":"Clough","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery Manchester University NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6109-5996","authenticated-orcid":false,"given":"Katie","family":"Nightingale","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Manchester University NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1971-7592","authenticated-orcid":false,"given":"Stella","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Manchester University NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4027-747X","authenticated-orcid":false,"given":"Joshua Richard","family":"Burke","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Manchester University NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,1]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102022\u2010062846"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13017\u2010022\u201000443\u2010x"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.21037\/cdt.2018.09.06"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10140\u2010011\u20100965\u20104"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261\u2010016\u20100988\u20100"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2014.09.015"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10844"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010019\u201006730\u20100"},{"key":"e_1_2_13_10_1","unstructured":"ClinicalTrials.gov \u201cIndocyanine Green Fluorescence Imaging in Prevention of Colorectal Anastomotic Leakage (ICG\u2010COLORAL) (NCT03602677) \u201d(2018) https:\/\/clinicaltrials.gov\/study\/NCT03602677."},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.14257"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_13_13_1","volume-title":"Investigating the Benefit of Fluorescence in Acute Mesenteric Ischaemia: A Systematic Review","author":"Clough E.","year":"2024"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j4008"},{"key":"e_1_2_13_15_1","unstructured":"Critical Appraisal Skills Programme \u201cCASP Checklist: Systematic Reviews With Meta\u2010Analysis of Observational Studies \u201d(2024) https:\/\/casp\u2010uk.net\/casp\u2010tools\u2010checklists\/systematic\u2010reviews\u2010meta\u2010analysis\u2010observational\u2010studies\/."},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj127"},{"key":"e_1_2_13_17_1","unstructured":"ROBINS\u2010I V2.\u201cRisk of Bias in Non\u2010Randomized Studies of Interventions \u201d(2016) https:\/\/www.riskofbias.info\/welcome\/robins\u2010i\u2010v2."},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-022-09136-7"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605\u2010018\u20103855\u20101"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2022.05.033"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13032"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.9738\/INTSURG-D-14-00038.1"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151\u2010014\u20101132\u20107"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000001529"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-018-6226-9"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.15680"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-021-02358-8"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13017\u2010025\u201000575\u2010w"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"}],"container-title":["ANZ Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.70433","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ans.70433","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.70433","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:49:54Z","timestamp":1777524594000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.70433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,1]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/ans.70433"],"URL":"https:\/\/doi.org\/10.1111\/ans.70433","archive":["Portico"],"relation":{},"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,1]]},"assertion":[{"value":"2025-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}