{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:01:02Z","timestamp":1790182862231,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>It is widely accepted that definitive surgical treatment for primary cutaneous melanoma should occur promptly, but the effects of a delay between initial diagnosis and definitive surgery remain unclear. In addition, high quality evidence is lacking for an optimal time\u2010to\u2010surgery from initial melanoma diagnosis. The aim of this study was to determine whether the timing of surgical treatment for Stage I &amp; II melanoma was associated with survival outcome and whether there was an optimal time interval between melanoma diagnosis and definitive surgical treatment with respect to survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective cohort study of patients with primary cutaneous melanoma treated at a single institution between 1990 and 2015. The associations between time\u2010to\u2010surgery and clinical outcomes including overall survival (OS) and recurrence\u2010free survival (RFS) were described using the Kaplan\u2013Meier method. Multivariable Cox proportional hazard models were used to quantify the relationship between each time\u2010to\u2010surgery cohort and clinical outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total 18, 242 patients were included in the analysis. Their average age was 57.5\u2009years and 57% were male. The majority of primary melanomas were located on the trunk (32.5%) and upper limb (24.7%). Mean Breslow thickness was 1.8\u2009mm (range 0.1\u201350\u2009mm) and 64% were of superficial spreading subtype. Time to surgery was divided into \u2264\u20091\u2009week, 1\u20134\u2009weeks, 4\u20138\u2009weeks, 8\u201312\u2009weeks and &gt;\u200912\u2009weeks (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092453, 8882, 5906, 870 and 126, respectively). Increased delay of definitive surgical treatment was associated with poorer OS and RFS, with an OS HR of 1.23 for the 8\u201312\u2009week group compared to the 1\u20134\u2009week group. For RFS HR was 1.36 for the same cohorts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Definitive surgical treatment of patients with primary cutaneous melanoma between 1\u20134\u2009weeks post\u2010diagnosis with excision\u2010biopsy was associated with improved OS &amp; RFS compared to those treated within 1\u2009week and greater than 4\u2009weeks in this patient cohort treated prior to the use of adjuvant drug therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ans.70490","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T10:32:01Z","timestamp":1768386721000},"page":"502-516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Timing of Definitive Surgical Management of Primary Cutaneous Melanoma: Association With Survival"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5622-1123","authenticated-orcid":false,"given":"Edward (Ned)","family":"Farley","sequence":"first","affiliation":[{"name":"Melanoma Institute Australia The University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5706-6903","authenticated-orcid":false,"given":"Jake","family":"Hindmarch","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia The University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"McKeown","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia The University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serigne N.","family":"Lo","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia The University of Sydney  Sydney Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney","family":"Ch'ng","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia The University of Sydney  Sydney Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Sydney Australia"},{"name":"Royal Prince Alfred Hospital  Sydney Australia"},{"name":"Chris O\u2019Brien Lifehouse  Sydney Australia"},{"name":"Mater Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omgo E.","family":"Nieweg","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia The University of Sydney  Sydney Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0210-057X","authenticated-orcid":false,"given":"Thomas E.","family":"Pennington","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia The University of Sydney  Sydney Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Sydney Australia"},{"name":"Royal Prince Alfred Hospital  Sydney Australia"},{"name":"Mater Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8538-3132","authenticated-orcid":false,"given":"Kerwin F.","family":"Shannon","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia The University of Sydney  Sydney Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Sydney Australia"},{"name":"Royal Prince Alfred Hospital  Sydney Australia"},{"name":"Chris O\u2019Brien Lifehouse  Sydney Australia"},{"name":"Mater Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Spillane","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia The University of Sydney  Sydney Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Sydney Australia"},{"name":"Mater Hospital  Sydney Australia"},{"name":"Royal North Shore Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2816-2496","authenticated-orcid":false,"given":"John F.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia The University of Sydney  Sydney Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Sydney Australia"},{"name":"Royal Prince Alfred Hospital  Sydney Australia"},{"name":"Mater Hospital  Sydney Australia"},{"name":"Faculty of Health and Medical Sciences The University of Western Australia  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn P. 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