{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T02:27:28Z","timestamp":1777861648945,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Traditionally bilateral cervical exploration (BCE) under general anaesthesia has been performed for cases of primary hyperparathyroidism (PHP) caused by a parathyroid adenoma. Imaging\u2010guided minimally invasive parathyroidectomy (MIP) has been shown to be equally efficacious with less morbidity. This systematic review and meta\u2010analysis aim to assess the safety and efficacy of MIP under locoregional anaesthesia (LRMIP) compared to general anaesthesia (GAMIP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>SCOPUS, Cochrane Library, PubMed and Google Scholar databases were searched from inception to August 2024 to identify eligible comparative studies investigating minimally invasive parathyroidectomy under locoregional anaesthesia (LRMIP) versus general anaesthesia (GAMIP). The primary outcomes were cure and side effects. Secondary outcomes were recurrent\/persistent hyperparathyroidism, post\u2010operative nausea and vomiting, pain, use of analgesia, operating time, length of hospital stay, and patient satisfaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seven research articles were included, two RCTs and five cohort studies, including 1046 patients. Cure rates, side effect profile, and recurrent\/persistent hyperparathyroidism were comparable between both groups. Trends towards reduced post\u2010operative nausea and vomiting were seen in LRMIP. The LRMIP group experienced a mean reduction of \u22121.26 for VAS pain scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.04) and required fewer analgesics. Patient satisfaction with LRMIP appears comparable to GAMIP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LRMIP appears comparable to GAMIP in respect of cure and safety profile, with reduced pain and potential benefits in PONV and recovery. LRMIP may be considered for selected patients undergoing parathyroidectomy for primary hyperparathyroidism. Larger prospective studies are needed prior to broader adoption.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ans.70536","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T05:15:19Z","timestamp":1771650919000},"page":"721-732","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Minimally Invasive Parathyroidectomy Performed Under Loco\u2010Regional Anaesthesia Versus General Anaesthesia: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1807-3745","authenticated-orcid":false,"given":"Cian","family":"Casey","sequence":"first","affiliation":[{"name":"Department of General Surgery Launceston General Hospital  Launceston Tasmania Australia"},{"name":"Department of General Surgery Fiona Stanley Hospital  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Department of General Surgery Launceston General Hospital  Launceston Tasmania Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9775-3599","authenticated-orcid":false,"given":"Nagendra N.","family":"Dudi\u2010Venkata","sequence":"additional","affiliation":[{"name":"Department of General Surgery Launceston General Hospital  Launceston Tasmania Australia"},{"name":"Division of Cancer Surgery, Peter MacCallum Cancer Centre Victorian Comprehensive Cancer Centre  Melbourne Victoria Australia"},{"name":"General Surgery and Gastrointestinal Clinical Institute Epworth Healthcare  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Tasevski","sequence":"additional","affiliation":[{"name":"Department of General Surgery Royal Melbourne Hospital  Melbourne Victoria Australia"},{"name":"University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Bazaadut","sequence":"additional","affiliation":[{"name":"Department of General Surgery Launceston General Hospital  Launceston Tasmania Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2005.03.036"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2007.04324.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199810)20:7<583::AID-HED1>3.0.CO;2-X"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199204000-00002"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31430-7"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(97)90201-4"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/msy.1998.92006"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3168"},{"issue":"5","key":"e_1_2_12_10_1","first-page":"410","article-title":"Minimally Invasive Parathyroid Surgery","volume":"4","author":"Noureldine S. I.","year":"2015","journal-title":"Gland Surgery"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2020.4021"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs5.77"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010787.pub2"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.137.9.1055"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2018.12.034"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2005.07.016"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200009000-00005"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2002.123853"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/std13020012"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.21037\/gs.2019.09.02"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5048"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3923\/ijp.2019.84.91"},{"issue":"4","key":"e_1_2_12_23_1","first-page":"361","article-title":"Minimally Invasive Parathyroidectomy Under Local Anesthesia: Patient Satisfaction and Overall Outcome","volume":"39","author":"Chau J. K. M.","year":"2010","journal-title":"Journal of Otolaryngology \u2013 Head & Neck Surgery = Le Journal d'oto\u2010rhino\u2010laryngologie et de chirurgie cervico\u2010faciale"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-002-6672-2"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9261-z"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-016-3514-1"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313480607201218"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2019.08.007"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13304-017-0447-7"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.4103\/sja.SJA_401_19"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-018-0632-3"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102636"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000941"},{"issue":"1","key":"e_1_2_12_34_1","first-page":"9","article-title":"The Impact of Endotracheal Tube Vs. Laryngeal Mask Airway on the Incidence of Postoperative Nausea and Vomiting: A Systemic Review and Meta\u2010Analysis","volume":"23","author":"Porhomayon J.","year":"2015","journal-title":"Middle East Journal of Anesthesiology"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcot.2022.101923"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9292"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-1633.12350"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4463"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1503\/cjs.013715"},{"issue":"4","key":"e_1_2_12_40_1","first-page":"9","article-title":"Day\u2010Case Parathyroidectomy as Standard: A Single Centre Experience of Safe Surgical Practice","volume":"30","author":"Chang J.","year":"2020","journal-title":"Journal of One\u2010Day Surgery"},{"issue":"2","key":"e_1_2_12_41_1","first-page":"N126","article-title":"Surgery in Primary Hyperparathyroidism: The Patient Without Previous Neck Surgery","volume":"17","author":"Udelsman R.","year":"2002","journal-title":"Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2013.04.020"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1015-9584(09)60225-6"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-2197.2002.02310.x"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2021.05.030"}],"container-title":["ANZ Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.70536","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ans.70536","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.70536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:41:09Z","timestamp":1777524069000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.70536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,20]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/ans.70536"],"URL":"https:\/\/doi.org\/10.1111\/ans.70536","archive":["Portico"],"relation":{},"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,20]]},"assertion":[{"value":"2025-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}