{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T02:27:41Z","timestamp":1777861661655,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Severe acute pancreatitis (SAP) can result in prolonged intensive care unit (ICU) admission and high mortality despite advances in supportive care. The outcomes of patients requiring extended ICU treatment remain poorly characterised. This study aimed to evaluate the clinical outcomes of patients with SAP requiring prolonged ICU admission at a tertiary referral centre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted at Alfred Health, Melbourne, including adult patients admitted with SAP over a 7\u2010year period. Patients with an ICU length of stay &gt;\u200914\u2009days were compared with those admitted for \u2264\u200914\u2009days. Data collected included demographics, aetiology, complications, interventions and in\u2010hospital outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 691 admissions with acute pancreatitis, 60 patients (8.7%) required ICU admission for SAP, of whom 17 (28.3%) remained in ICU &gt;\u200914\u2009days. Alcohol\u2010related aetiology was most common (33%). Patients with prolonged ICU stay experienced significantly higher rates of pancreatic necrosis (58.8% vs. 14.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), multiorgan failure (76.5% vs. 14.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and respiratory failure (94.1% vs. 25.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Mortality in the prolonged ICU group was higher (35.3% vs. 14.3%), though two\u2010thirds ultimately survived to hospital discharge. Prolonged ICU stay was also associated with greater need for invasive interventions and extended total hospitalisation (median 48 vs. 14\u2009days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite the complexity and duration of illness, two\u2010thirds of patients with ICU stays beyond 2\u2009weeks survived to discharge, indicating that extended organ support should not be viewed as futile. These findings underscore the importance of sustained multidisciplinary care and support continued active management in selected patients with severe disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ans.70550","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T10:30:41Z","timestamp":1773397841000},"page":"905-911","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of Patients With Severe Acute Pancreatitis Requiring Prolonged Intensive Care Admission at a Tertiary Centre: A Retrospective Cohort Study"],"prefix":"10.1111","volume":"96","author":[{"given":"Chen","family":"Lew","sequence":"first","affiliation":[{"name":"Department of General Surgery the Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1532-7730","authenticated-orcid":false,"given":"Morgan","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of General Surgery the Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6851-4030","authenticated-orcid":false,"given":"Helen","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of General Surgery the Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Khaleel","sequence":"additional","affiliation":[{"name":"Department of General Surgery the Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Hassum","sequence":"additional","affiliation":[{"name":"Department of General Surgery the Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Pilgrim","sequence":"additional","affiliation":[{"name":"Department of General Surgery the Alfred Hospital  Melbourne Victoria Australia"},{"name":"Department of General Surgery Peninsula Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.17215"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja14.01333"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.06.073"},{"issue":"2","key":"e_1_2_10_5_1","first-page":"179","article-title":"Utilization of Intensive Care Unit Resources in Severe Acute Pancreatitis","volume":"9","author":"Lilja H. 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