{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T04:03:39Z","timestamp":1792296219181,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Phyllodes tumours of the breast exhibit a spectrum of biologic behaviour, with a predisposition to recur locally and metastasize distantly in their malignant form. There are limited data regarding the optimal surgical approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Our systematic review and meta\u2010analysis aimed to determine the impact of breast conserving surgery (BCS) compared to mastectomy on overall survival (OS), disease\u2010free survival (DFS), and local recurrence (LR) for patients with borderline and malignant phyllodes tumours to guide treatment planning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>We identified relevant studies from PubMed, MEDLINE, Embase, and Google Scholar using the updated PRISMA Guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review Methods<\/jats:title>\n                    <jats:p>\n                      Included studies compared breast conservation and mastectomy and reported rates of OS, DFS, and LR for individuals with borderline or malignant phyllodes tumours. A random\u2010effects model was used to pool relative risk data. Heterogeneity was assessed using Cochran's\n                      <jats:italic>Q<\/jats:italic>\n                      statistic.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 1950 screened by our search, 13 studies were deemed suitable for inclusion. These studies included 874 patients undergoing breast conservation and 784 undergoing mastectomy. The median follow\u2010up time was 65\u2009months. There was improved OS following BCS in the malignant (pooled RR 0.9, 95% CI 0.85\u20130.95) and combined borderline and malignant cohorts (pooled RR 0.91, 95% CI 0.86\u20130.95). There was no difference in DFS in the malignant or combined cohorts. LR risk was increased following BCS in both malignant (pooled RR 2.47, 95% CI 1.64\u20133.72) and combined cohorts (pooled RR 2.25, 95% CI 1.66\u20133.04). There was no significant heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>For individuals with borderline or malignant phyllodes tumours, BCS should be offered, where feasible, as part of an individualised multidisciplinary approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ans.70585","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T05:29:36Z","timestamp":1773206976000},"page":"1450-1458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of Surgical Approach on Survival and Recurrence in Borderline and Malignant Phyllodes Tumours: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3087-2462","authenticated-orcid":false,"given":"Christopher G.","family":"Harris","sequence":"first","affiliation":[{"name":"The University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Breast Surgery Chris O'brien Lifehouse  Sydney New South Wales Australia"},{"name":"Department of Surgery Royal Prince Alfred Hospital  Sydney New South Wales Australia"},{"name":"Department of Breast Surgery Wollongong Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Heller","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Chris O'brien Lifehouse  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Azimi","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Chris O'brien Lifehouse  Sydney New South Wales Australia"},{"name":"Department of Surgery Royal Prince Alfred Hospital  Sydney New South Wales Australia"},{"name":"The University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Chris O'brien Lifehouse  Sydney New South Wales Australia"},{"name":"Department of Surgery Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susannah","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Chris O'brien Lifehouse  Sydney New South Wales Australia"},{"name":"Department of Surgery Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Mak","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Chris O'brien Lifehouse  Sydney New South Wales Australia"},{"name":"Department of Surgery Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Warrier","sequence":"additional","affiliation":[{"name":"The University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Breast Surgery Chris O'brien Lifehouse  Sydney New South Wales Australia"},{"name":"Department of Surgery Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_2_13_2_1","volume-title":"Diseases of the Breast","author":"Calhoun K. 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