{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:41:13Z","timestamp":1783021273031,"version":"3.54.6"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The management of patients with colorectal liver metastases (CRLM) is complex and requires a tailored approach based on disease extent, patient age, and comorbidities. Given the heterogeneity in presentation and evolving treatment algorithms, prognostic factors for long\u2010term survival following liver resection are contested. This study aimed to evaluate \u201creal\u2010world\u201d outcomes in patients with long\u2010term follow\u2010up after potentially curative liver resection at a tertiary Australian center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on prospectively collected data from patients who underwent first\u2010time liver resection for CRLM between 1998 and 2018. Standardized clinical, biochemical, and radiological follow\u2010up was undertaken. Multivariable Cox regression analysis was used to identify independent predictors of overall survival (OS), measured from the diagnosis of liver metastases to death or last contact.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 396 patients who underwent resection, 320 met the inclusion criteria. The median follow\u2010up was 123.3\u2009months (95% CI: 110.5\u2013131.0), median OS was 69.6\u2009months (95% CI: 57.2\u201384.5), and the 10\u2010year OS rate was 33%; 5\u2010year and 10\u2010year disease\u2010free survival rates were 29% and 25%, respectively. Neoadjuvant chemotherapy was administered in 72% of patients, with 25% receiving targeted therapy in this setting. Postoperative (adjuvant or recurrence\u2010related) chemotherapy was given to 50% of patients, with 17% also receiving targeted therapy. Independent predictors of poor OS included older age, right\u2010sided primary tumours, large liver tumours, administration of locoregional liver therapy, and the use of chemotherapy \u00b1 targeted therapy in both the neoadjuvant and adjuvant settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>One\u2010third of patients who undergo liver resection for CRLM achieve long\u2010term survival. While multi\u2010modal therapy was commonly used, determining the specific contribution of non\u2010surgical treatments is challenging in a real\u2010world cohort where treatment paradigms evolved over time. This study provides rare 10\u2010year follow\u2010up data and reinforces the need for ongoing refinement of personalised management strategies for CRLM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ans.70658","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T05:46:18Z","timestamp":1775540778000},"page":"1678-1690","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Two Decades of Multimodal Management of Colorectal Liver Metastases With Long\u2010Term Outcomes"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4319-4189","authenticated-orcid":false,"given":"Ali","family":"Mohtashami","sequence":"first","affiliation":[{"name":"Upper Gastrointestinal Surgical Department Royal North Shore Hospital  St Leonards New South Wales 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