{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:40:25Z","timestamp":1783021225423,"version":"3.54.6"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Cholangiocarcinoma (CCA) is a malignancy of the bile duct epithelium. Its incidence is highest in Northeast Thailand, where it is strongly associated with\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Opisthorchis viverrini<\/jats:italic>\n                      <\/jats:styled-content>\n                      (OV) infection. The only curative treatment for intrahepatic cholangiocarcinoma (IHCCA), the most common subtype, is surgical resection. This study aimed to investigate survival outcomes and identify factors associated with long\u2010term survival in resectable IHCCA patients in the high\u2010incidence of OV infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included all patients who underwent curative\u2010intent hepatic resection for pathologically confirmed IHCCA at Sakon Nakhon Hospital between January 2016 and December 2023. Survival was analysed using Kaplan\u2013Meier method. Univariate and multivariate Cox proportional hazard regression models were used to identify prognosis factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 63 patients were included. The 30\u2010day and 90\u2010day mortality rate were 1.6% and 6.3%, respectively. The median overall survival was 28.5\u2009months (95% CI: 13.79\u201343.13). The 1\u2010year, 3\u2010year, and 5\u2010year survival rates were 71.1%, 43.5%, and 30.1%, respectively. In the multivariate analysis, factors significantly associated with poorer survival were advanced disease (Stages III and IV) (adjusted hazard ratios [aHR]\u2009=\u20093.37; 95% CI: 1.63\u20136.97) and lymphovascular invasion (LVI) (aHR\u2009=\u20092.55; 95% CI: 1.27\u20135.11).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The median survival and 5\u2010year survival in this study are consistent with outcomes from previous studies. Advanced disease stage and the presence of LVI are independent predictors of poor survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ans.70704","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T05:40:36Z","timestamp":1777095636000},"page":"1691-1697","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intrahepatic Cholangiocarcinoma Surgery Outcomes and Survival Factors in an\n                    <scp>\n                      <i>Opisthorchis viverrini<\/i>\n                    <\/scp>\n                    \u2010Endemic Area"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7917-4024","authenticated-orcid":false,"given":"Nisit","family":"Tongsiri","sequence":"first","affiliation":[{"name":"Department of Surgery Sakon Nakhon Hospital, Ministry of Public Health  Sakon Nakhon Sakon Nakhon Province Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rawin","family":"Ingsirorat","sequence":"additional","affiliation":[{"name":"Department of Surgery Udon Thani Cancer Hospital, Department of Medical Services, Ministry of Public Health  Udon Thani Udon Thani Province Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2023.0035"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.11.020"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2010.07.006"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70096-8"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.09.007"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.04067.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2016.17.1.401"},{"issue":"4","key":"e_1_2_11_9_1","first-page":"141","article-title":"Survival and Treatment Outcomes of Resectable Cholangiocarcinoma: Initial Experience in Khon Kaen Hospital","volume":"44","author":"Theerachotpakorn P.","year":"2023","journal-title":"Thai Journal of Surgery"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2022.11.027"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-017-3499-6"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-019-04996-y"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2020.21.4.903"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08247-z"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.6519"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07968-7"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2013.5137"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/08941939.2014.880138"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S282519"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/pst.2090"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2010.12.002"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2010.10.001"},{"issue":"1","key":"e_1_2_11_24_1","first-page":"1","article-title":"Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. 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