{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:44:44Z","timestamp":1783035884096,"version":"3.54.6"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Colorectal cancer is one of the most common cancers in Aotearoa New Zealand. Evidence supports that right colon cancer (RCC) and left colon cancer (LCC) represent distinct entities, with RCC associated with a poorer prognosis, despite accounting for stage. Oncogenic mutations in MMR protein expression, BRAF V600E, and RAS genes have been shown to differ significantly between RCC and LCC, influencing tumour behaviour and prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Histopathologic features of RCC and LCC in patients treated between 2018 and 2023 in a centre in Aotearoa New Zealand were evaluated. RCC was defined as arising from caecum to distal transverse colon, and LCC from splenic flexure to rectosigmoid junction. The primary outcomes were the rates of deficient MMR protein expression (dMMR), BRAF V600E, and NRAS gene mutations. Secondary outcomes included tumour characteristics, lymph node status, and AJCC prognostic stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 376 patients were included, for a total of 390 tumours. RCC had a higher rate of dMMR tumours compared to LCC (50.4% vs. 13.75%; adjusted OR 6.36, 95% CI: 3.57\u201311.35). There were no significant differences in the rates of BRAF V600E or NRAS gene mutations between sides. RCC was more likely to be mucinous adenocarcinoma (23% RCC vs. 10% LCC; OR 2.99, 95% CI: 1.64\u20135.49), and to be high\u2010grade (18.7% vs. 12.5%; OR 1.68, 95% CI: 1.03\u20132.92) compared to LCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RCC was associated with a higher rate of dMMR and high\u2010grade tumours, and a greater proportion of mucinous adenocarcinomas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ans.70727","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T04:50:27Z","timestamp":1778129427000},"page":"1727-1733","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of Histopathologic Features of Right and Left Sided Colon Cancer"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1563-2390","authenticated-orcid":false,"given":"A.","family":"Petrie","sequence":"first","affiliation":[{"name":"Department of General Surgery Tauranga Hospital  Tauranga New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5089-2807","authenticated-orcid":false,"given":"D. A.","family":"Carson","sequence":"additional","affiliation":[{"name":"Department of General Surgery Tauranga Hospital  Tauranga New Zealand"},{"name":"Department of Surgery University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Cribb","sequence":"additional","affiliation":[{"name":"Department of General Surgery Tauranga Hospital  Tauranga New Zealand"},{"name":"New Zealand Graduate School of Medicine University of Waikato  Hamilton New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"\u201cCancer Data Web Tool [Internet] \u201d(2025) https:\/\/tewhatuora.shinyapps.io\/cancer\u2010web\u2010tool\/."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.4227"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i21.6470"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju427"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14495"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.4414"},{"key":"e_1_2_6_8_1","volume-title":"National Statement on Ethical Conduct in Human Research 2023","author":"National Health and Medical Research Council, Australian Research Council, Universities Australia","year":"2023"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-021-04005-6"},{"key":"e_1_2_6_10_1","volume-title":"Digestive System Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2019"},{"key":"e_1_2_6_11_1","first-page":"1032","volume-title":"AJCC Cancer Staging Manual","author":"Amin M. 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