{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:14:51Z","timestamp":1788347691627,"version":"build-2803163510"},"reference-count":8,"publisher":"Wiley","issue":"7-8","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral antibiotics usually given for 24\u2009h prior to surgery have been shown to result in lower anastomotic leak rates, as a result of luminal decontamination. Delivering antibiotics into the lumen of the intestine at the time of surgery may be a simpler way to achieve this outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An audit was undertaken of the first 50 consecutive patients undergoing luminal peri\u2010anastomotic antibiotic washout performed by a single surgeon at two surgical institutions. The luminal washout initially involved metronidazole (500\u2009mg) and gentamicin (240\u2009mg) followed by the addition of ampicillin (1000\u2009mg) for latter patients. The combined solution was delivered to the lumen of both sides of the colorectal anastomosis using either a soaked Raytec surgical gauze or syringe, or both. Follow up was performed for 30\u2009days to assess for anastomotic leak, complications, clostridium difficile colitis and acute kidney injury, and at 90\u2009days for mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The 30 and 90\u2009day mortality was zero. There were no anastomotic leaks and no cases of clostridium difficile colitis. Complications occurred in six patients, with three readmissions within 30\u2009days. There were no cases of acute kidney injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Peri\u2010anastomotic luminal washout with antibiotics is feasible and safe. It does not appear to have deleterious effects and should be compared to peri\u2010operative oral antibiotics in larger clinical trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ans.70733","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T05:39:48Z","timestamp":1778305188000},"page":"2052-2055","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Luminal Peri\u2010Anastomotic Antibacterial Washout to Prevent Colorectal Anastomotic Leakage: A Pilot Audit of Outcomes"],"prefix":"10.1111","volume":"96","author":[{"given":"Daniel","family":"Cattanach","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery Calvary Mater and John Hunter Hospitals  Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1104-133X","authenticated-orcid":false,"given":"Stephen Ridley","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Calvary Mater and John Hunter Hospitals  Newcastle New South Wales Australia"},{"name":"Hunter Surgical Clinical Research Unit  Newcastle New South Wales Australia"},{"name":"School of Medicine and Health University of Newcastle  Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Lott","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Calvary Mater and John Hunter Hospitals  Newcastle New South Wales Australia"},{"name":"Hunter Surgical Clinical Research Unit  Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2253-4233","authenticated-orcid":false,"given":"Yui","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Calvary Mater and John Hunter Hospitals  Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Nadarajah","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Calvary Mater and John Hunter Hospitals  Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"e_1_2_7_2_1","article-title":"Collagen Degradation and MMP9 Activation by \n                     Enterococcus faecalis\n                   Contribute to Intestinal Anastomotic Leak","volume":"7","author":"Shogun B. D.","year":"2015","journal-title":"Science Translational Medicine"},{"key":"e_1_2_7_3_1","first-page":"439","article-title":"Influence of the Microbiome on Anastomotic Leak","volume":"6","author":"Williamson A. J.","year":"2021","journal-title":"Clinics in Colon and Rectal Surgery"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001041"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD014909.pub2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-195505000-00016"},{"key":"e_1_2_7_7_1","first-page":"123","article-title":"Strangulation Obstruction; Effect of Pre\u2010 and Postoperative Antibacterial Agents; a Preliminary Report","author":"Cohn I.","year":"1951","journal-title":"Surgical Forum"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(76)90419-0"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-328389"}],"container-title":["ANZ Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.70733","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ans.70733","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.70733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:33:13Z","timestamp":1788345193000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.70733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,8]]},"references-count":8,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/ans.70733"],"URL":"https:\/\/doi.org\/10.1111\/ans.70733","archive":["Portico"],"relation":{},"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,8]]},"assertion":[{"value":"2026-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}