{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:04:32Z","timestamp":1790251472183,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100013684","name":"Christie Charity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013684","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Resection of major vascular structures may be required to achieve R0 resection in pelvic exenteration surgery for advanced pelvic malignancy. The evidence base for pelvic oncovascular techniques is limited, with patient outcomes following these procedures not widely reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This systematic review synthesises the current literature on R0 resection and 30\u2010day mortality rates following oncovascular pelvic exenteration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review was conducted according to a pre\u2010defined protocol (PROSPERO ID CRD42024613055). MEDLINE, EMBASE, Cochrane Library and Web of Science were interrogated between January 1, 1947, to July 1, 2025. Studies exploring oncovascular resection in advanced pelvic malignancy were considered. Pre\u20101980 studies were included narratively but excluded from quantitative synthesis. Data were extracted on R0 resection, postoperative morbidity and mortality. The ROBINS\u20101\u2009V2 tool was used to assess bias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventeen studies met the inclusion criteria. After excluding three pre\u20101980 studies, 411 contemporary patients were included in quantitative analysis. Among curative\u2010intent procedures (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009334), the R0 resection rate was 65.3% (218\/334). With regards to morbidity, Clavien\u2013Dindo grade I\u2013II complications occurred in 56.9% (227\/399) and grade III\u2013IV complications in 28.5% (109\/382). Thirty\u2010day mortality was 1.9% (8\/411). Median overall survival was 41\u2009months (range 34\u201357.6), with median disease\u2010free survival of 27\u2009months (range 8\u201343.2).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Approximately two thirds of patients undergoing oncovascular pelvic exenteration achieved R0 resection, with morbidity and 30\u2010day mortality of 1.9%. Outcomes remain inferior to contemporary benchmark series for conventional exenteration, reflecting the pioneering phase of oncovascular practice. Centralisation, rigorous audit and benchmarking and improved patient selection should be the focus of future work to improve R0 and complication rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ans.70824","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:29:06Z","timestamp":1783481346000},"page":"2308-2320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oncovascular Resection in Pelvic Exenteration: A Systematic Review"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4027-747X","authenticated-orcid":false,"given":"Joshua Richard","family":"Burke","sequence":"first","affiliation":[{"name":"Colorectal &amp; Peritoneal Oncology Centre The Christie NHS Foundation Trust  Manchester UK"},{"name":"Division of Cancer Sciences, Manchester Cancer Research Centre The University of Manchester  Manchester UK"},{"name":"Manchester Vascular Centre Manchester University NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7930-8196","authenticated-orcid":false,"given":"Yasmin","family":"Oskui","sequence":"additional","affiliation":[{"name":"Colorectal &amp; Peritoneal Oncology Centre The Christie NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3435-3563","authenticated-orcid":false,"given":"Imogen","family":"Samuel","sequence":"additional","affiliation":[{"name":"Colorectal &amp; Peritoneal Oncology Centre The Christie NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Wild","sequence":"additional","affiliation":[{"name":"Colorectal &amp; Peritoneal Oncology Centre The Christie NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0967-8515","authenticated-orcid":false,"given":"Kilian G.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery and Surgical Outcomes Research Centre Royal Prince Alfred Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1008-8275","authenticated-orcid":false,"given":"Jonathan","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Colorectal &amp; Peritoneal Oncology Centre The Christie NHS Foundation Trust  Manchester UK"},{"name":"Manchester Vascular Centre Manchester University NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7452-0282","authenticated-orcid":false,"given":"Paul A.","family":"Sutton","sequence":"additional","affiliation":[{"name":"Colorectal &amp; Peritoneal Oncology Centre The Christie NHS Foundation Trust  Manchester UK"},{"name":"Division of Cancer Sciences, Manchester Cancer Research Centre The University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"426","article-title":"Excision of Major Blood Vessels at the Periphery of the Pelvis in Patients Receiving Pelvic Exenteration: Common and\/or Iliac Arteries and Veins 1947 to 1964","volume":"62","author":"Barber H. R.","year":"1967","journal-title":"Surgery"},{"key":"e_1_2_11_3_1","first-page":"672","article-title":"The Surgical Treatment of Cancer of the Cervix Uteri; a Radical Operation for Cancer of the Cervix","volume":"24","author":"Brunschwig A.","year":"1948","journal-title":"Bulletin of the New York Academy of Medicine"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2016.10.028"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2023.01.018"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2011.08.131"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2023.10.021"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znac414"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.16476"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000006348"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.14969"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280216669183"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195801\/02)11:1<48::AID-CNCR2820110112>3.0.CO;2-M"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02554852"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.931569"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181a73f48"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9915"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znab070"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000421"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e31827dbcb0"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v10.i3.811"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-017-1638-4"},{"key":"e_1_2_11_25_1","first-page":"498","article-title":"Resection of the Great Veins on the Lateral Pelvic Wall","volume":"88","author":"Brunschwig A.","year":"1949","journal-title":"Surgery, Gynecology & Obstetrics"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001819"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.26665"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1411"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.16948"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.106868"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2015.01.028"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.6034"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.02525"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3182196e1f"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.16740"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctro.2025.100934"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2010.01.026"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2277"}],"container-title":["ANZ Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.70824","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ans.70824","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.70824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:16:18Z","timestamp":1790248578000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.70824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,7]]},"references-count":37,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/ans.70824"],"URL":"https:\/\/doi.org\/10.1111\/ans.70824","archive":["Portico"],"relation":{},"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,7]]},"assertion":[{"value":"2025-12-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}