{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:05:15Z","timestamp":1789236315401,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Lung cancer surgery is associated with significant perioperative morbidity, including pulmonary complications and psychological distress. The effectiveness of comprehensive interdisciplinary care models in improving outcomes remains insufficiently studied.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This single\u2010center randomized controlled trial enrolled 240 patients undergoing lung cancer surgery between March 2021 and December 2023. Patients were randomized 1:1 to receive either an interdisciplinary integrated care intervention (\n n<\/jats:italic>\n \u2009=\u2009120) or standard care (\n n<\/jats:italic>\n \u2009=\u2009120). The intervention included preoperative pulmonary rehabilitation, psychological support, nutritional optimization, and enhanced postoperative recovery protocols. The primary outcome was postoperative length of hospital stay (\n LOS<\/jats:styled-content>\n ). Secondary outcomes included postoperative pulmonary complications (\n PPCs<\/jats:styled-content>\n ), pain scores, functional recovery (6\u2010min walk distance), psychological status (\n HADS<\/jats:styled-content>\n ), and quality of life (\n QLQ<\/jats:styled-content>\n \u2010\n C30<\/jats:styled-content>\n ). Intention\u2010to\u2010treat analysis was performed as the primary analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In the\n ITT<\/jats:styled-content>\n analysis, the intervention group had significantly shorter\n LOS<\/jats:styled-content>\n compared to control (7.43\u2009\u00b1\u20091.94 vs. 9.02\u2009\u00b1\u20092.30\u2009days; mean difference 1.59\u2009days, 95%\n CI<\/jats:styled-content>\n : 1.07\u20132.12;\n p<\/jats:italic>\n \u2009<\u20090.001; Cohen's\n d<\/jats:italic>\n \u2009=\u20090.75). After adjusting for baseline\n FEV1<\/jats:styled-content>\n imbalance, the difference remained significant (adjusted mean difference 1.54\u2009days, 95%\n CI<\/jats:styled-content>\n : 1.02\u20132.06;\n p<\/jats:italic>\n \u2009<\u20090.001).\n PPCs<\/jats:styled-content>\n were significantly lower in the intervention group (12.0% vs. 26.1%;\n RR<\/jats:styled-content>\n \u2009=\u20090.46, 95%\n CI<\/jats:styled-content>\n : 0.26\u20130.81;\n p<\/jats:italic>\n \u2009=\u20090.008). The intervention group demonstrated superior functional recovery, with 6\u2010min walk distance differences of 57.77\u2009m at 1\u2009month and 61.97\u2009m at 3\u2009months, both exceeding the minimal clinically important difference of 22\u201342\u2009m. Psychological outcomes (\n HADS<\/jats:styled-content>\n \u2010anxiety: 4.19\u2009\u00b1\u20092.55 vs. 6.48\u2009\u00b1\u20093.22;\n HADS<\/jats:styled-content>\n \u2010Depression: 3.57\u2009\u00b1\u20091.97 vs. 5.19\u2009\u00b1\u20092.89 at 3\u2009months; both\n p<\/jats:italic>\n \u2009<\u20090.001) and quality of life were significantly improved.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n An interdisciplinary integrated care model significantly reduces hospital stay, decreases pulmonary complications, and improves functional and psychological outcomes in patients undergoing lung cancer surgery. These findings support the implementation of comprehensive perioperative care programs.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ans.70841","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T14:49:30Z","timestamp":1785077370000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness of an Interdisciplinary Integrated Care Model on Perioperative Outcomes in Patients Undergoing Lung Cancer Surgery: A Randomized Controlled Trial"],"prefix":"10.1111","author":[{"given":"Xingu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Zhujiang Hospital of Southern Medical University Guangzhou City Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nili","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Zhujiang Hospital of Southern Medical University Guangzhou City Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Zhujiang Hospital of Southern Medical University Guangzhou City Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuping","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Zhujiang Hospital of Southern Medical University Guangzhou City Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Zhujiang Hospital of Southern Medical University Guangzhou City Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Zhujiang Hospital of Southern Medical University Guangzhou City Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5242-0363","authenticated-orcid":false,"given":"Yan","family":"Yu","sequence":"additional","affiliation":[{"name":"High\u2010Quality Medical Service Office Zhujiang Hospital of Southern Medical University Guangzhou City Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,26]]},"reference":[{"issue":"3","key":"e_1_2_11_2_1","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung H.","year":"2021","journal-title":"CA: A Cancer Journal for Clinicians"},{"issue":"12","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e32821","article-title":"Incidence and Risk Factors of Pulmonary Complications After Lung Cancer Surgery: A Systematic Review and Meta\u2010Analysis","volume":"10","author":"Chen S.","year":"2024","journal-title":"Heliyon"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.2147\/COPD.S105206","article-title":"Prevalence of and Risk Factors for Postoperative Pulmonary Complications After Lung Cancer Surgery in Patients With Early\u2010Stage COPD","volume":"11","author":"Kim E. 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