{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:05:47Z","timestamp":1790251547650,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Salivary gland malignancy (SGM) is a rare and heterogeneous head and neck neoplasm. Curative treatment often mandates upfront surgery. Patients with high\u2010risk features receive adjuvant radiotherapy. This study aims to investigate the clinicopathological characteristics, survival outcomes and prognostic factors for primary SGM in an Australian population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study of adult patients with primary SGM diagnosed between January 2001 and December 2024 at our institution was conducted. Clinicopathological and treatment characteristics were collected. Overall survival (OS), recurrence\u2010free survival (RFS) and disease\u2010free survival (DFS) were calculated. Log\u2010rank univariate analysis and multivariate Cox regression analysis were conducted to determine prognostic factors for OS and DFS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 149 patients were included. The median follow\u2010up time was 59\u2009months (IQR 22.75\u201396\u2009months). Patients were mostly male (57.7%) with a median age of 59\u2009years (IQR 48\u201371\u2009years). Tumours were most commonly located in the parotid gland (81.2%). The most common histological subtype was mucoepidermoid carcinoma (26.2%). The 5\u2010 and 10\u2010year OS, RFS and DFS were 81.9% and 77.9%, 78.5% and 71.8% and 84.6% and 82.6%, respectively. Independent prognostic factors for OS were ECOG 2\/3 (HR 19.059, 95% CI [3.061\u2013118.664]), T3\/4 (HR 6.925 [2.871\u201316.703]) and intermediate\/high grade (HR 3.310 [1.122\u20139.761]). Independent prognostic factors for DFS were ECOG 2\/3 (HR 64.267 [7.758\u2013532.400]), T3\/4 (HR 8.085 [3.008\u201321.729]) and intermediate\/high grade (HR 8.065 [1.774\u201336.660]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Survival outcomes for primary SGM significantly differ between subtypes. Independent prognostic factors for OS and DFS are ECOG 2\/3, T3\/4 and intermediate\/high grade.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ans.70891","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T05:00:49Z","timestamp":1786338049000},"page":"2455-2464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Survival Outcomes and Prognostic Factors of Primary Salivary Gland Malignancy: A 24\u2010Year Retrospective Cohort Study"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0714-9601","authenticated-orcid":false,"given":"Jacinta","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Royal North Shore Hospital  St Leonards New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Royal North Shore Hospital  St Leonards New South Wales Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3791-4925","authenticated-orcid":false,"given":"Leba M.","family":"Sarkis","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Royal North Shore Hospital  St Leonards New South Wales Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"},{"name":"Chris O'Brien Lifehouse  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5954-8065","authenticated-orcid":false,"given":"Andrew","family":"Wignall","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Royal North Shore Hospital  St Leonards New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4324-1886","authenticated-orcid":false,"given":"Thomas","family":"Eade","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Radiation Oncology Royal North Shore Hospital  St Leonards New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1547-8077","authenticated-orcid":false,"given":"Sarah","family":"Bergamin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Radiation Oncology Royal North Shore Hospital  St Leonards New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5363-3974","authenticated-orcid":false,"given":"Dasantha","family":"Jayamanne","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Radiation Oncology Royal North Shore Hospital  St Leonards New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3811-2916","authenticated-orcid":false,"given":"Anna","family":"Lawless","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Radiation Oncology Royal North Shore Hospital  St Leonards New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1422-0198","authenticated-orcid":false,"given":"Venkatesha","family":"Venkatesha","sequence":"additional","affiliation":[{"name":"Northern Sydney Local Health District Executive Royal North Shore Hospital  St Leonards New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5814-1218","authenticated-orcid":false,"given":"David","family":"Veivers","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Royal North Shore Hospital  St Leonards New South Wales Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-06205-2"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27236"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815594789"},{"key":"e_1_2_10_5_1","volume-title":"Head and Neck Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2022"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.09.005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.12205"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.16421"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40618-3"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30135"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27376"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjph-2023-000551"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-023-07940-y"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph191610247"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2018.05.002"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-019-05454-0"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2022.106052"},{"issue":"1","key":"e_1_2_10_18_1","first-page":"E1838","article-title":"Salivary Duct Carcinoma: Clinicopathologic Features, Morphologic Spectrum, and Somatic Mutations","volume":"38","author":"Luk P. P.","year":"2016","journal-title":"Head & Neck"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000436"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000291"}],"container-title":["ANZ Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.70891","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ans.70891","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.70891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:15:44Z","timestamp":1790248544000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.70891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,9]]},"references-count":19,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/ans.70891"],"URL":"https:\/\/doi.org\/10.1111\/ans.70891","archive":["Portico"],"relation":{},"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,9]]},"assertion":[{"value":"2026-02-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}