{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T04:28:27Z","timestamp":1793593707333,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Aim<\/jats:title>\n Primary colorectal lymphoma (PCL) is a rare gastrointestinal malignancy with heterogeneous pathology and limited evidence to guide management, particularly in the Australian setting. This study aimed to describe the epidemiology, treatment patterns and short\u2010 to medium\u2010term outcomes of patients with PCL in Queensland.<\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n A retrospective population\u2010based cohort study was performed using the Queensland Oncology Repository. Patients with histologically confirmed primary colorectal lymphoma diagnosed between January 2000 and July 2017 were included, excluding those with prior or synchronous extra\u2010colorectal lymphoma. Demographic, clinicopathological, treatment and outcome data were analysed. Disease\u2010specific survival was assessed to 3\u2009years using Kaplan\u2013Meier methods, with Gehan's test applied.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 173 patients were identified. Diffuse large B\u2010cell lymphoma was the most common histological subtype (60.1%), and the right colon was the most frequently involved site (60.7%). Combined chemotherapy and surgery were the most frequently employed treatments (43.9%). Three\u2010year disease\u2010specific survival was 83%. Treatment modality was the strongest determinant of survival (\n p<\/jats:italic>\n \u2009<\u20090.001), with chemotherapy\u2010based regimens associated with superior outcomes. Surgery alone was associated with poor disease\u2010specific survival, with a 45% disease\u2010related mortality. Increasing age (\u2265\u200965\u2009years) was independently associated with inferior disease survival (\n p<\/jats:italic>\n \u2009=\u20090.006).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This population\u2010based study represents the largest Australian cohort of primary colorectal lymphoma reported to date. PCL predominantly affects older males and is most commonly treated with chemotherapy\u2010based regimens, which are associated with favourable survival. Surgery alone should not be considered definitive therapy except in selected clinical circumstances.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ans.70908","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T02:32:11Z","timestamp":1786501931000},"page":"3135-3143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Management and Outcomes of Primary Colorectal Lymphomas in Queensland: A Retrospective Study"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8887-0200","authenticated-orcid":false,"given":"Yaying (Eileen)","family":"Xu","sequence":"first","affiliation":[{"name":"Department of General Surgery Royal Brisbane and Women's Hospital Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Royal Brisbane and Women's Hospital Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2065-3012","authenticated-orcid":false,"given":"David","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of General Surgery Royal Brisbane and Women's Hospital Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2019.05.004"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.5048"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25582"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001373"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.21037\/jgo.2017.10.08"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2017.01.011"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/gidisord7010014"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2019.06.034"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100038\u20101642048"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605\u2010011\u20101572\u20100"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001279"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i6.697"},{"issue":"5","key":"e_1_2_13_14_1","first-page":"902","article-title":"Primary Colorectal Lymphoma: Clinicopathologic Features and Outcome of a Population\u2010Based Study","volume":"8","author":"Wong M. T.","year":"2017","journal-title":"Journal of Gastrointestinal Oncology"},{"issue":"7","key":"e_1_2_13_15_1","first-page":"2283","article-title":"Clinical Characteristics and Prognostic Factors of Primary Colorectal Lymphoma: A Multicenter Retrospective Study","volume":"9","author":"Zhai L. Z. Y.","year":"2020","journal-title":"Cancer Medicine"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185\u2010019\u201002687\u2010x"},{"key":"e_1_2_13_17_1","unstructured":"National Comprehensive Cancer Network (NCCN) \u201cB\u2010Cell Lymphomas Version 3 \u201d2023."},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2025.109346"}],"container-title":["ANZ Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.70908","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ans.70908","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.70908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T04:25:21Z","timestamp":1793593521000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.70908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,11]]},"references-count":17,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/ans.70908"],"URL":"https:\/\/doi.org\/10.1111\/ans.70908","archive":["Portico"],"relation":{},"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,11]]},"assertion":[{"value":"2026-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}