{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T02:13:20Z","timestamp":1788488000648,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Negative pressure wound therapy (NPWT) reduces wound complications following oncoplastic breast surgery, yet there is limited evidence supporting its use in mastectomy without reconstruction. This study evaluated the effect of NPWT on post\u2010mastectomy wound complications in a rural Australian centre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single centre retrospective cohort study assessed simple mastectomy outcomes between 2020 and 2025. Wounds were grouped by post\u2010operative dressing type (NPWT vs. no NPWT). The primary outcome was a composite of aspirated seroma, haematoma, wound dehiscence, and surgical site infection (SSI). Secondary outcomes were individual wound complications and intervention\u2010related outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The 131 mastectomy wounds were included (NPWT\u2009=\u200959). There was no significant difference in the composite wound outcome between NPWT and no NPWT (62.71% vs. 47.22%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.077). NPWT had significantly more aspirated seromas (59.32% vs. 40.28%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030) but multivariate analysis did not identify a significant association (Multivariate Exp (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      ) (95% CI): 2.021 (0.958\u20134.265);\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.065). No significant difference was identified in the other secondary outcomes. Diabetes mellitus was independently associated with the composite wound complication (Multivariate Exp (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      ) (95% CI): 3.349 (1.242\u20139.031);\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017) and increasing body mass index was associated with SSI (Multivariate Exp (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      ) (95% CI): 1.064 (1.012\u20131.119);\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NPWT was not associated with reduced wound complications following simple mastectomy. Aspirated seroma was more common for NPWT, but regression analysis found no significant association. A high rate of wound complications poses a significant burden for patients and this regional centre; prospective data is required to determine optimal the way to prevent and manage said complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ans.70951","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T01:36:19Z","timestamp":1788485779000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Negative Pressure Wound Therapy Does Not Reduce Wound Complications Following Simple Mastectomy: A Retrospective Cohort Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9678-4783","authenticated-orcid":false,"given":"Robert","family":"Torode","sequence":"first","affiliation":[{"name":"Department of General Surgery North West Regional Hospital  Burnie Tasmania Australia"},{"name":"Rural Clinical School, UTAS Health University of Tasmania  Burnie Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5117-0939","authenticated-orcid":false,"given":"David","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of General Surgery North West Regional Hospital  Burnie Tasmania Australia"},{"name":"Rural Clinical School, UTAS Health University of Tasmania  Burnie Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Fong","sequence":"additional","affiliation":[{"name":"Department of General Surgery North West Regional Hospital  Burnie Tasmania Australia"},{"name":"Regional Training Hub, UTAS Health University of Tasmania  Burnie Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.51678"},{"key":"e_1_2_13_3_1","volume-title":"Cancer Data in Australia","author":"AIHW","year":"2025"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2013.14.1.539"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znac275"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyl019"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-13831-9"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2007.11"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2015.108"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.21037\/abs-24-35"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2006.03949.x"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-024-08881-w"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2012.02.179"},{"issue":"6","key":"e_1_2_13_14_1","article-title":"Negative Pressure Wound Therapy for Surgical Wounds Healing by Primary Closure","volume":"6","author":"Norman G.","year":"2020","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-025-18738-z"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000004936"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2024.07.333"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-89036-3"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znag056"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-023-07042-7"},{"key":"e_1_2_13_21_1","volume-title":"Rural and Remote Health","author":"AIHW","year":"2025"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.52232"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-019050"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.13710"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.6092"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.12828"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000005130"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-019-05335-x"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000005028"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-017-4651-4"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2009.02.010"},{"key":"e_1_2_13_32_1","volume-title":"Tobacco in Australia: Facts & Issues","author":"Greenhalgh E. M.","year":"2025"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2025.111967"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.0295"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntq158"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.9328"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2021.09.007"}],"container-title":["ANZ Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.70951","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ans.70951","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.70951","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T01:36:21Z","timestamp":1788485781000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.70951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,3]]},"references-count":36,"alternative-id":["10.1111\/ans.70951"],"URL":"https:\/\/doi.org\/10.1111\/ans.70951","archive":["Portico"],"relation":{},"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,3]]},"assertion":[{"value":"2026-06-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ans.70951"}}