{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T05:02:12Z","timestamp":1789794132109,"version":"4.0.1"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The Australian National Bowel Cancer Screening Program began in 2006, offering free faecal occult blood testing every 2\u2009years to Australians aged 50\u201375\u2009years. We hypothesised a difference in overall survival between screen\u2010detected and non\u2010screen\u2010detected colorectal cancer in an Australian cohort, for each stage I\u2013III.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>A retrospective cohort study of patients with stage I\u2013III colorectal cancer from 2010 to 2024 was conducted using a prospectively maintained institutional database. Overall survival (OS) was calculated from the date of diagnosis. Kaplan\u2013Meier analysis and log\u2010rank testing were used to compare survival between screen\u2010detected and non\u2010screen\u2010detected cancers, stratified by stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 881 colorectal cancer episodes were included, of which 254 (28.8%) were screen\u2010detected. The proportion of screen\u2010detected cancers increased significantly over time (Cochran\u2013Armitage trend test,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Screen\u2010detected cancers were diagnosed at an earlier stage, with a significantly higher proportion of stage I disease than non\u2010screen\u2010detected cancers (38.6% vs. 18.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Five\u2010year OS for stage I disease was 93.9% in the screen\u2010detected group and 90.8% in the non\u2010screen\u2010detected group (HR 0.62, 95% CI 0.30\u20131.28;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.19). Corresponding five\u2010year OS for stage II disease was 91.3% and 85.6%, respectively (HR 0.70, 95% CI 0.33\u20131.48;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.35). In stage III disease, 81.5% vs. 68.9%, respectively (HR 0.56, 95% CI 0.34\u20130.92;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Screen\u2010detected colorectal cancer is associated with earlier stage at diagnosis and improved survival in stage III disease. These findings support the role of screening in earlier diagnosis and improved oncological outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ans.70984","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:20:36Z","timestamp":1789791636000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of the\n                    <scp>A<\/scp>\n                    ustralian National Bowel Cancer Screening Program on Stage at Diagnosis and Stage\u2010Specific Survival in Colorectal Cancer"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6741-7562","authenticated-orcid":false,"given":"Michael","family":"Rouse","sequence":"first","affiliation":[{"name":"Department of Surgery, Western Precinct University of Melbourne  Melbourne Victoria Australia"},{"name":"Department of Colorectal Surgery Footscray Hospital, Western Health  Footscray Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8254-8687","authenticated-orcid":false,"given":"Michael","family":"Harold","sequence":"additional","affiliation":[{"name":"Gibbs Lab Walter and Eliza Hall Institute of Medical Research  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Wong","sequence":"additional","affiliation":[{"name":"Gibbs Lab Walter and Eliza Hall Institute of Medical Research  Parkville Victoria Australia"},{"name":"Oncology Department Sunshine Hospital, Western Health  St Albans Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Lee","sequence":"additional","affiliation":[{"name":"Oncology Department Sunshine Hospital, Western Health  St Albans Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6341-257X","authenticated-orcid":false,"given":"Fiona","family":"Reid","sequence":"additional","affiliation":[{"name":"Department of Surgery, Western Precinct University of Melbourne  Melbourne Victoria Australia"},{"name":"Department of Colorectal Surgery Footscray Hospital, Western Health  Footscray Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7230-149X","authenticated-orcid":false,"given":"Justin M.","family":"Yeung","sequence":"additional","affiliation":[{"name":"Department of Surgery, Western Precinct University of Melbourne  Melbourne Victoria Australia"},{"name":"Department of Colorectal Surgery Footscray Hospital, Western Health  Footscray Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1423-4484","authenticated-orcid":false,"given":"Peter","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Gibbs Lab Walter and Eliza Hall Institute of Medical Research  Parkville Victoria Australia"},{"name":"Oncology Department Sunshine Hospital, Western Health  St Albans Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4015-4931","authenticated-orcid":false,"given":"Ian","family":"Faragher","sequence":"additional","affiliation":[{"name":"Department of Surgery, Western Precinct University of Melbourne  Melbourne Victoria Australia"},{"name":"Department of Colorectal Surgery Footscray Hospital, Western Health  Footscray Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"National Bowel Cancer Screening Program Monitoring Report 2025","author":"Quintero A.","year":"2025"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1364923"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.0007"},{"key":"e_1_2_12_5_1","unstructured":"PDQ Screening and Prevention Editorial Board \u201cPDQ Colorectal Cancer Screening \u201dNational Cancer Institute Updated 10\/04\/2025 https:\/\/www.cancer.gov\/types\/colorectal\/hp\/colorectal\u2010screening\u2010pdq. accessed May 01 2026."},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12916"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkab100"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.23671"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2025.1433"},{"key":"e_1_2_12_10_1","unstructured":"Australian Institute of Health and Welfare \u201cNational Bowel Cancer Screening Program Monitoring Report 2025: Glossary and Program Definitions \u201dAIHW 2025 accessed July 27 2026 https:\/\/www.aihw.gov.au\/reports\/cancer\u2010screening\/nbcsp\u2010monitoring\u20102025\/contents\/glossary."},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2024.5227"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2026.2404"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.498"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.08.033"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.16232"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0969141316656216"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2023.12.015"}],"container-title":["ANZ Journal of 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