{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T14:16:58Z","timestamp":1762352218117,"version":"3.40.4"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,2,9]],"date-time":"2013-02-09T00:00:00Z","timestamp":1360368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the diagnostic characteristics of the evaluation of myometrial invasion (<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>) retrospectively between preoperative magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) and intraoperative frozen sections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Sample<\/jats:title><jats:p>201 women diagnosed with endometrial carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All women underwent preoperative<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>and 111 of them also underwent intraoperative frozen section assessment. The final pathological evaluation was used as the definitive diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>In women who underwent<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>and frozen sections (n\u00a0=\u00a0111), the accuracies of detection of<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>and of deep invasion (defined as \u226550% invasion) were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The accuracy, sensitivity, and specificity of<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>for detection of<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>were 65.8, 58.8, and 88.5%, and those in frozen sections were 90.1, 90.6, and 88.5%, respectively. The accuracy and sensitivity of frozen sections were significantly higher (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001,<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001), whereas the specificity of the two methods did not differ (<jats:italic>p\u00a0<\/jats:italic>=\u00a01.000). The accuracy, sensitivity, and specificity of<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>for detection of deep invasion were 83.8, 69.2, and 88.2%, and those of frozen sections were 93.7, 73.1, and 100.0%, respectively. The accuracy and specificity of frozen sections were significantly higher (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.007 and<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001, respectively), whereas sensitivity did not show a significant difference (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.999).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In assessment of<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>, the accuracy of frozen sections was significantly higher than that of<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>. Since the diagnostic characteristics differ between two methods, additional intraoperative frozen sections are recommended for more accurate assessment of<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>when<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>is negative for the presence of any<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>or positive for the presence of deep invasion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12048","type":"journal-article","created":{"date-parts":[[2012,11,16]],"date-time":"2012-11-16T19:41:07Z","timestamp":1353094867000},"page":"525-535","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Preoperative and intraoperative assessment of myometrial invasion in endometrial cancer: comparison of magnetic resonance imaging and frozen sections"],"prefix":"10.1111","volume":"92","author":[{"given":"Iori","family":"Kisu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Keio University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouji","family":"Banno","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Keio University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"The Center for Clinical Research School of Medicine Keio University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihisa","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology School of Medicine Keio University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Abe","sequence":"additional","affiliation":[{"name":"The Center for Clinical Research School of Medicine Keio University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Kouyama","sequence":"additional","affiliation":[{"name":"The Center for Clinical Research School of Medicine Keio University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Okuda","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology School of Medicine Keio University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Masugi","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Keio University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoko","family":"Umene","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Keio University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuya","family":"Nogami","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Keio University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Keio University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenta","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Keio University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arisa","family":"Ueki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Keio University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Keio University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Yamagami","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Keio University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Susumu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Keio University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Keio University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,9]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.3322\/caac.20138"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1148\/radiographics.19.4.g99jl06937"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1016\/0002-9378(80)91024-8"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1016\/0090-8258(89)90027-9"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1016\/S0140-6736(08)61766-3"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_1","DOI":"10.1006\/gyno.1996.4573"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1016\/j.ygyno.2003.11.032"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.1111\/IGC.0b013e3181ad3eb6"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_1","DOI":"10.1148\/radiol.2312021184"},{"doi-asserted-by":"publisher","key":"e_1_2_8_11_1","DOI":"10.1007\/s00330-006-0555-0"},{"key":"e_1_2_8_12_1","first-page":"413","article-title":"ACOG practice bulletin, clinical management guidelines for obstetrician\u2010gynecologists, number 65, August 2005: management of endometrial cancer","volume":"106","author":"American College of Obstetricians and Gynecologists","year":"2005","journal-title":"Obstet Gynecol."},{"doi-asserted-by":"publisher","key":"e_1_2_8_13_1","DOI":"10.2214\/ajr.158.3.1738995"},{"doi-asserted-by":"publisher","key":"e_1_2_8_14_1","DOI":"10.1016\/0090-8258(89)90115-7"},{"doi-asserted-by":"publisher","key":"e_1_2_8_15_1","DOI":"10.1002\/1097-0142(19901015)60:8 <2035::AID-CNCR2820601515>3.0.CO;2-8"},{"doi-asserted-by":"publisher","key":"e_1_2_8_16_1","DOI":"10.1016\/S0140-6736(09)62002-X"},{"doi-asserted-by":"publisher","key":"e_1_2_8_17_1","DOI":"10.1093\/jnci\/djn397"},{"key":"e_1_2_8_18_1","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1097\/IGC.0b013e318221eb92","article-title":"Intraoperative frozen section assessment of myometrial invasion and histology of endometrial cancer using the revised FIGO staging system","volume":"21","author":"Ugaki H","year":"2011","journal-title":"Int J Gynecol Cancer."},{"doi-asserted-by":"publisher","key":"e_1_2_8_19_1","DOI":"10.1016\/j.crad.2006.03.011"},{"doi-asserted-by":"publisher","key":"e_1_2_8_20_1","DOI":"10.1111\/IGC.0b013e3181a7a2d9"},{"doi-asserted-by":"publisher","key":"e_1_2_8_21_1","DOI":"10.1016\/j.ygyno.2006.10.007"},{"doi-asserted-by":"publisher","key":"e_1_2_8_22_1","DOI":"10.1016\/j.ygyno.2005.12.028"},{"doi-asserted-by":"publisher","key":"e_1_2_8_23_1","DOI":"10.1080\/00016340903141135"},{"doi-asserted-by":"publisher","key":"e_1_2_8_24_1","DOI":"10.1016\/j.ejogrb.2007.02.029"},{"doi-asserted-by":"publisher","key":"e_1_2_8_25_1","DOI":"10.1111\/j.1471-0528.2001.00196.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_26_1","DOI":"10.1016\/0002-9378(92)91600-F"},{"doi-asserted-by":"publisher","key":"e_1_2_8_27_1","DOI":"10.1097\/01.AOG.0000245444.14015.00"},{"doi-asserted-by":"publisher","key":"e_1_2_8_28_1","DOI":"10.1111\/j.1525-1438.2006.00414.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_29_1","DOI":"10.1111\/IGC.0b013e3181e9509f"},{"doi-asserted-by":"publisher","key":"e_1_2_8_30_1","DOI":"10.1016\/j.ijgo.2009.02.012"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faogs.12048","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.12048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T01:53:01Z","timestamp":1745200381000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.12048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,9]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1111\/aogs.12048"],"URL":"https:\/\/doi.org\/10.1111\/aogs.12048","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"type":"print","value":"0001-6349"},{"type":"electronic","value":"1600-0412"}],"subject":[],"published":{"date-parts":[[2013,2,9]]},"assertion":[{"value":"2012-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-11-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}