{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T18:22:08Z","timestamp":1771784528400,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T00:00:00Z","timestamp":1358726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>In general, epidemiological studies have evaluated cases with congenital cardiovascular abnormalities together. The aim of this study is to describe the birth outcomes of cases with isolated\/single atrial septal defect type <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, i.e. only a fossa ovalis defect) after surgical correction or lethal outcome in the light of maternal sociodemographic data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Comparison of birth outcomes and maternal characteristics of cases with <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> and controls without defect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>The population\u2010based Hungarian Case\u2010Control Surveillance of Congenital Abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Hungarian newborn infants with or without <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medically recorded birth outcomes, maternal age and birth order were evaluated. Marital and employment status was based on maternal information. The lifestyle factors were analyzed in a subsample of mothers visited at home based on a personal interview with mothers and their close relatives, and the family consensus was accepted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Mean gestational age at delivery and birthweight, rate of preterm birth and low birthweight, maternal age, birth order, marital and employment status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The evaluation of 471 cases with <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> and 38\u00a0151 controls without any defects showed a female excess in cases with <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, having shorter gestational age and lower mean birthweight, and thus a higher rate of preterm births and low birthweight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intrauterine growth restriction and shorter gestational age were found in cases with <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, particularly in female children. These factors may have a general developmental process in which there was not closure of the foramen ovale, thus echocardiographic screening of these babies might be of value.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12062","type":"journal-article","created":{"date-parts":[[2012,12,5]],"date-time":"2012-12-05T22:22:46Z","timestamp":1354746166000},"page":"824-829","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Birth outcomes of cases with isolated atrial septal defect type II \u2013 a population\u2010based case\u2010control study"],"prefix":"10.1111","volume":"92","author":[{"given":"Attila","family":"Vereczkey","sequence":"first","affiliation":[{"name":"Versys Clinics Human Reproduction Institute Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"K\u00f3sa","sequence":"additional","affiliation":[{"name":"Versys Clinics Human Reproduction Institute Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melinda","family":"Cs\u00e1ky\u2010Szunyogh","sequence":"additional","affiliation":[{"name":"National Centre for Healthcare Audit and Inspection Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00f3bert","family":"Urb\u00e1n","sequence":"additional","affiliation":[{"name":"Institute of Psychology E\u00f6tv\u00f6s Lor\u00e1nd University Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew E.","family":"Czeizel","sequence":"additional","affiliation":[{"name":"Foundation for the Community Control of Hereditary Diseases Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,21]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"191","article-title":"Incidence of congenital heart defects in Budapest","volume":"13","author":"Czeizel AE","year":"1972","journal-title":"Acta Paediat Acad Sci Hung"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01886-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025312603880"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2003.05.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.958405"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000152769"},{"key":"e_1_2_8_8_1","first-page":"1855","volume-title":"Hurst's the Heart","author":"Fulton DR","year":"2008"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)36830-4"},{"key":"e_1_2_8_10_1","unstructured":"FerenczC LoffredoCA RubinJD MageeCA.Epidemiology of congenital heart diseases. 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