{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:20:36Z","timestamp":1790396436055,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T00:00:00Z","timestamp":1358726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To test the effect of 800\u00a0\u03bcg of misoprostol orally on the prevention of manual removal of retained placenta.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Multicenter, double\u2010blinded, placebo\u2010controlled, randomized trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>One university and one non\u2010university teaching hospital in the Netherlands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Sample<\/jats:title><jats:p>99 women with retained placenta (longer than 60\u00a0min after childbirth) in the absence of postpartum hemorrhage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eligible women were administered either 800\u00a0\u03bcg of misoprostol or placebo orally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Number of manual removals of retained placenta and amount of blood loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Manual removal of retained placenta was performed in 50% of the women who received misoprostol and in 55% who received placebo (relative risk 0.91, 95% confidence interval 0.62\u20131.34). No difference in the amount of blood loss (970 vs. 1120\u00a0mL; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.34) was observed between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Administration of 800\u00a0\u03bcg of oral misoprostol, one hour after childbirth, does not seem to reduce the number of manual removals of retained placentas. The time elapsing results in the delivery of 50% of the retained placentas at the expense of an increased risk of postpartum hemorrhage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12065","type":"journal-article","created":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T17:01:30Z","timestamp":1355245290000},"page":"398-403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["No reduction of manual removal after misoprostol for retained placenta: a double\u2010blind, randomized trial"],"prefix":"10.1111","volume":"92","author":[{"given":"Giel","family":"van Stralen","sequence":"first","affiliation":[{"name":"Department of Obstetrics Leiden University Medical Centre Leiden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke","family":"Veenhof","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Leiden University Medical Centre Leiden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cas","family":"Holleboom","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Bronovo Hospital Den Haag the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos","family":"van Roosmalen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Leiden University Medical Centre Leiden"},{"name":"Department of Medical Humanities EMGO Institute for Health and Care Research VU University Medical Center Amsterdam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,21]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"CD001337","article-title":"Umbilical vein injection for management of retained placenta (review)","volume":"5","author":"Nardin JM","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(01)00592-9"},{"key":"e_1_2_10_4_1","volume-title":"The prevention and management of postpartum haemorrhage: report of a technical working group. 3\u20136 July 1989","author":"World Health Organization","year":"1989"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1997.tb12020.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016340701330054"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00111-7"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2003.09.011"},{"key":"e_1_2_10_9_1","unstructured":"Farmacotherapeutisch kompas.http:\/\/www.cvzkompassen.nl; 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