{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T22:25:05Z","timestamp":1768256705182,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T00:00:00Z","timestamp":1365465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To present the results of a large series of patients with ovarian hyperstimulation syndrome treated with a conservative medical approach and to compare the cost of this treatment with outpatient management with paracentesis according to published data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective case series and cost analysis study using a decision\u2010tree model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>496 consecutive patients with ovarian hyperstimulation syndrome treated in our center from 1991 to 2010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients were treated with a conservative medical approach: (a) conservative outpatient approach: bed rest and a low\u2010sodium diet or (b) hospitalized patients: bed rest, low\u2010sodium diet, 20% albumin (60\u00a0g\/day) and furosemide (20\u00a0mg\/8\u00a0h).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Percentage of admissions, length of hospital stay and readmissions. Total cost of each therapeutic approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>(a) Conservative outpatient approach (<jats:italic>n<\/jats:italic>\u00a0=\u00a0377): all cases solved without admission. (b) Hospitalized patients with conservative medical treatment (<jats:italic>n<\/jats:italic>\u00a0=\u00a0119): 2.8\u00a0days of mean hospital stay, no patient required paracentesis or admission to intensive care unit. Readmissions: Five patients (4.2%) resolved on restarting medical treatment. (c) Cost\u2010analysis comparison: Cost of the outpatient approach with paracentesis: <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>$980 (range <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>$519\u20133557). Cost of conservative medical treatment: <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>$570 (range <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>$232\u20131640).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ovarian hyperstimulation syndrome can be safely managed with a conservative medical approach, which was not found to be more expensive than outpatient management with paracentesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12128","type":"journal-article","created":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T16:10:20Z","timestamp":1362413420000},"page":"686-691","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Conservative medical treatment of ovarian hyperstimulation syndrome: a single center series and cost analysis 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