{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:49:52Z","timestamp":1773409792680,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2013,9]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>A study was undertaken to assess the distribution of high\u2010risk HPV<\/jats:styled-content>\u2010genotypes in high\u2010grade cervical intraepithelial neoplastic lesions in Danish women.<\/jats:p><\/jats:sec>Design<\/jats:title>Observational, cross\u2010sectional.<\/jats:p><\/jats:sec>Setting<\/jats:title>Danish data from a multi\u2010centre study undertaken in 13 European countries.<\/jats:p><\/jats:sec>Population<\/jats:title>290 archived fixed biopsies with high\u2010grade cervical lesions from the Departments of Pathology at the University Hospitals in Hvidovre and Odense, Denmark.<\/jats:p><\/jats:sec>Methods<\/jats:title>Relevant histological samples were anonymized and shipped to a central laboratory for histopathology review and PCR<\/jats:styled-content>\u2010testing for HPV<\/jats:styled-content>\u2010DNA<\/jats:styled-content>. A standardised HPV<\/jats:styled-content>\u2010test methodology was utilised to enable comparison of HPV<\/jats:styled-content>\u2010genotype distribution.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 290 Danish cervical samples, 276 were evaluated as histologically adequate and all of these were HPV<\/jats:styled-content>\u2010positive (HPV<\/jats:styled-content>+<\/jats:sup>). Of the HPV<\/jats:styled-content>+<\/jats:sup> samples 77.9% were diagnosed with a single HPV<\/jats:styled-content>\u2010type, with cervical intraepithelial neoplasia (CIN<\/jats:styled-content>)3 diagnosed in 82.3% and CIN<\/jats:styled-content>2, CIN<\/jats:styled-content>2\/3, adenocarcinoma in situ (AIS<\/jats:styled-content>) and AIS<\/jats:styled-content>+<\/jats:sup> other high\u2010grade lesion diagnosed in the remaining 17.7%. The most prevalent HPV<\/jats:styled-content>\u2010types were: HPV<\/jats:styled-content>16 (54.0%), HPV<\/jats:styled-content>33 (13.5%), HPV<\/jats:styled-content>31 (10.7%), HPV<\/jats:styled-content>18 (7.9%) and HPV<\/jats:styled-content>52 (4.7%). Of the HPV<\/jats:styled-content>+<\/jats:sup> samples, 21.4% were diagnosed with multiple HPV<\/jats:styled-content>\u2010types, with CIN<\/jats:styled-content>3 diagnosed in 79.6% and CIN<\/jats:styled-content>2, CIN<\/jats:styled-content>2\/3, AIS<\/jats:styled-content> and AIS<\/jats:styled-content>+<\/jats:sup> other high\u2010grade lesion diagnosed in the remaining 20.4%. The most prevalent HPV<\/jats:styled-content>\u2010types were: HPV<\/jats:styled-content>16 (49.2%), HPV<\/jats:styled-content>31 (30.5%), HPV<\/jats:styled-content>52 (27.1%), HPV<\/jats:styled-content>51 (20.3%), HPV<\/jats:styled-content>18 (16.9%), HPV<\/jats:styled-content>33 (13.6%), HPV<\/jats:styled-content>45 (11.9%), with 0.7% unknown types.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>HPV<\/jats:styled-content>16 and HPV<\/jats:styled-content>18 were detected in approximately 75% of high\u2010grade intraepithelial cervical lesions in a Danish population (single or multiple infections); these two genotypes are considered causative in at least 61.9% of the high\u2010grade intraepithelial lesions (single infection).<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12162","type":"journal-article","created":{"date-parts":[[2013,5,6]],"date-time":"2013-05-06T11:20:41Z","timestamp":1367839241000},"page":"1032-1040","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["HPV<\/scp>\u2010genotypes in high\u2010grade intraepithelial cervical lesions in Danish women"],"prefix":"10.1111","volume":"92","author":[{"given":"Benny","family":"Kirschner","sequence":"first","affiliation":[{"name":"Department of Gynecology & Obstetrics Hvidovre University Hospital Copenhagen Denmark"},{"name":"Department of Pathology Hvidovre University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doris","family":"Schledermann","sequence":"additional","affiliation":[{"name":"Department of Pathology Odense University Hospital Odense 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