{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T22:11:04Z","timestamp":1781043064782,"version":"3.54.1"},"reference-count":11,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T00:00:00Z","timestamp":1370476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the efficacy of 5% lidocaine 25\u00a0mg\u2013prilocaine 25\u00a0mg\/g cream (<jats:styled-content style=\"fixed-case\">EMLA<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup>) applied to the uterine cervix for reducing pain during diagnostic or operative hysteroscopy, using a visual analogue scale (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>) for pain in a prospective randomized, non\u2010blinded, controlled study in 92 successive patients. Patients were randomized to either 3\u00a0mL of <jats:styled-content style=\"fixed-case\">EMLA<\/jats:styled-content> cream or 3\u00a0mL of ultrasound gel (placebo), placed endocervically and exocervically, 10\u00a0min before hysteroscopy. Intensity of pain was evaluated immediately after the procedure using a 10\u2010cm <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>. No differences were found between the two groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.07). The number of women who wished to stop the procedure was significantly lower in the <jats:styled-content style=\"fixed-case\">EMLA<\/jats:styled-content> group compared with the control group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.013). We concluded that topical instillation of <jats:styled-content style=\"fixed-case\">EMLA<\/jats:styled-content> does not decrease pain during hysteroscopy, but does reduce a desire to abandon the procedure.<\/jats:p>","DOI":"10.1111\/aogs.12165","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T07:12:20Z","timestamp":1368083540000},"page":"978-981","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Lidocaine\u2010prilocaine (<scp>EMLA<\/scp><sup>\u00ae<\/sup>) cream as analgesia in hysteroscopy practice: a prospective, randomized, non\u2010blinded, controlled study"],"prefix":"10.1111","volume":"92","author":[{"given":"Baldomero","family":"Arnau","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Service Health Consortium of Terrassa Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Jovell","sequence":"additional","affiliation":[{"name":"Epidemiology Service Health Consortium of Terrassa Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Red\u00f3n","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Service Health Consortium of Terrassa Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Canals","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Service Health Consortium of Terrassa Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Mir","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Service Health Consortium of Terrassa Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Service Health Consortium of Terrassa Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,6]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"362","article-title":"Local anaesthesia with lidocaine\/prilocaine cream (EMLA) for cautery of condyloma acuminata on the vulval mucosa. The effect of timing of application of the cream","volume":"69","author":"Ljunghall K","year":"1989","journal-title":"Acta Derm Ven\u00e9relo"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.2340\/0001555573456458","article-title":"Duration of analgesia following application of eutectic mixture of local anaesthetics (EMLA) on genital mucosa","volume":"73","author":"Burght M","year":"1993","journal-title":"Acta Derm Ven\u00e9relo"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2010.07.009"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-3804(97)80019-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c1130"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2010.11.018"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2010.08.015"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del517"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(97)00183-5"},{"key":"e_1_2_8_11_1","unstructured":"Royal College of Obstetricians and Gynaecologists (RCOG) British Society for Gynecological Endoscopy 2011 Royal College of Obstetricians and Gynaecologists London"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.02.056"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faogs.12165","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.12165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T18:48:12Z","timestamp":1696531692000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.12165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,6]]},"references-count":11,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/aogs.12165"],"URL":"https:\/\/doi.org\/10.1111\/aogs.12165","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,6]]},"assertion":[{"value":"2012-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}