{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:18:07Z","timestamp":1785842287579,"version":"3.56.0"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,10,14]],"date-time":"2013-10-14T00:00:00Z","timestamp":1381708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate whether human epididymis protein 4 (<jats:styled-content style=\"fixed-case\">HE<\/jats:styled-content>4) and<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>125 correlate with known high\u2010risk prognostic factors for endometrial cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective multicenter study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Three Danish tertiary gynecological oncology centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 352 patients with endometrial cancer and atypical endometrial hyperplasia consecutively referred between 1 September 2009 and 1 January 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Preoperative blood samples were obtained from all patients. Biomarker levels were correlated with pathological characteristics of hysterectomy specimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">FIGO<\/jats:styled-content>stage, depth of myometrial invasion, cervical involvement, lymph node metastases, and histological type and grade of tumor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that both<jats:styled-content style=\"fixed-case\">HE<\/jats:styled-content>4 and<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>125 were significantly positively correlated with histological grade (<jats:styled-content style=\"fixed-case\">HE<\/jats:styled-content>4:<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002 and<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>125:<jats:italic>p<\/jats:italic>\u00a0=\u00a00.027), lymph node metastases (<jats:styled-content style=\"fixed-case\">HE<\/jats:styled-content>4:<jats:italic>p<\/jats:italic>\u00a0=\u00a00.013 and<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>125:<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.0001), myometrial invasion (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001) and cervical involvement (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). Furthermore, a significant increase was found with increasing<jats:styled-content style=\"fixed-case\">FIGO<\/jats:styled-content>stage for both markers (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). In a combined index including age, the diagnostic value increases. Area under the receiver operating characteristics curves were higher for the index compared with the markers individually for all our endpoints. The calculated plots for the combined index may assist gynecologists in predicting the risk of deep myometrial invasion, cervical involvement and lymph node metastases. The analyses emphasize that the combined markers should be used in the prediction of prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study confirmed that the markers are significantly elevated in patients with prognostic high\u2010risk factors and may, therefore, be used as an additional tool in combination with imaging and clinical information when planning the treatment of endometrial cancer patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12235","type":"journal-article","created":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T10:40:43Z","timestamp":1377168043000},"page":"1313-1322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["<scp>HE<\/scp>4 and<scp>CA<\/scp>125 levels in the preoperative assessment of endometrial cancer patients: a prospective multicenter study (<scp>ENDOMET<\/scp>)"],"prefix":"10.1111","volume":"92","author":[{"given":"Sofie L.","family":"Antonsen","sequence":"first","affiliation":[{"name":"Gynecologic Clinic Rigshospitalet, Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estrid","family":"H\u00f8gdall","sequence":"additional","affiliation":[{"name":"Department of Pathology Danish Cancer Biobank Herlev University Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ib J.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Finsen Laboratory Rigshospitalet, Copenhagen University Hospital Copenhagen Denmark"},{"name":"Biotech Research and Innovation Centre (BRIC) University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Lydolph","sequence":"additional","affiliation":[{"name":"Division of Microbiology and Diagnostics Department of Clinical Biochemistry and Immunology Statens Serum Institute Copenhagen 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