{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:56:53Z","timestamp":1791579413607,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T00:00:00Z","timestamp":1381795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the possible role of anti\u2010M\u00fcllerian hormone (<jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>) in the diagnosis of polycystic ovary syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>) with a larger population of women and to evaluate its role as a new diagnostic marker.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 570 women, with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a0419) and without <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a0151).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum basal hormone; <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>, follicle stimulating hormone (<jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content>), luteinizing hormone (<jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content>), prolactin, and thyroid\u2010stimulating hormone (<jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content>) levels were measured. Mean hormone levels were compared and the predictive value of serum <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> level was evaluated with the use of the receiver operating characteristic (<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>) curve analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No statistically significant differences were found between <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> women and control groups in terms of age, body mass index and <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> levels. Differences between mean serum, <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> LH<\/jats:styled-content> and estradiol levels and <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content> ratio were found to be statistically significant (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001). Mean serum <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> level was higher in <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> women than in controls (7.34 vs. 2.24\u00a0ng\/mL, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001). The area under the <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curve assay yielded a satisfactory result of 0.916 (95% confidence interval 0.897\u20130.935, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.0001). The best compromise between 89.8% specificity and 80% sensitivity was obtained with a cut\u2010off value of 3.94\u00a0ng\/mL for <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> measurement is very valuable in the diagnosis of <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> women. The serum <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> level in women with hyperandrogenism or oligo\u2010anovulation could indicate the diagnosis of <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> when reliable ultrasonography data are not available or when typical clinical and laboratory findings are not available. The serum <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> level is a new and useful diagnostic tool in <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12247","type":"journal-article","created":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T04:54:52Z","timestamp":1377665692000},"page":"1369-1374","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Elevated serum levels of anti\u2010M\u00fcllerian hormone can be introduced as a new diagnostic marker for polycystic ovary syndrome"],"prefix":"10.1111","volume":"92","author":[{"given":"Sezai","family":"Sahmay","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Division of Reproductive Endocrinology Cerrahpasa Medical Faculty Istanbul University Istanbul 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Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Seyisoglu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Division of Reproductive Endocrinology Cerrahpasa Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61345-2"},{"key":"e_1_2_9_3_1","unstructured":"1992 Blackwell Boston MA J Zawadzki A Dunaif A Dunaif J Givens F Haseltine G Merriam Diagnostic criteria for polycystic ovary syndrome: toward a rational approachPolycystic ovarian syndrome 377 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