{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:31:44Z","timestamp":1792809104611,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,17]],"date-time":"2013-12-17T00:00:00Z","timestamp":1387238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Although the levonorgestrel\u2010releasing intrauterine system (<jats:styled-content style=\"fixed-case\">LNG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IUS<\/jats:styled-content>) is effective in reducing the recurrence of endometriosis\u2010associated pain, its efficacy in preventing endometrioma recurrence is questionable. We compared the efficacy of postoperative use of<jats:styled-content style=\"fixed-case\">LNG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IUS<\/jats:styled-content>with oral contraceptives (<jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>) for preventing endometrioma recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Medical university hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Ninety\u2010nine women with endometriomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A chart review was performed of women of reproductive age who had undergone laparoscopic surgery for endometrioma followed by three cycles of gonadotropin\u2010releasing hormone agonist (leuprolide acetate) treatment. Women were categorized into two groups: a group that had postoperative<jats:styled-content style=\"fixed-case\">LNG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IUS<\/jats:styled-content>placement (<jats:italic>n<\/jats:italic>\u00a0=\u00a042) and a group that received postoperative, cyclic, low\u2010dose, monophasic,<jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>s (<jats:italic>n<\/jats:italic>\u00a0=\u00a057).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Endometrioma recurrence was analyzed according to several clinical variables and postoperative treatment modalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the follow\u2010up period (median 17\u00a0months), recurrent endometriomas were detected in eight women (8.1%). Patients with<jats:styled-content style=\"fixed-case\">LNG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IUS<\/jats:styled-content>had a recurrence rate of 4.8% (2\/42), whereas women receiving<jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>had a recurrence rate of 10.5% (6\/57). Cumulative recurrence\u2010free survival assessment revealed that mean disease\u2010free survival times for both groups were similar, but that for<jats:styled-content style=\"fixed-case\">LNG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IUS<\/jats:styled-content>was slightly longer than that for<jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>, with statistical significance (34.4\u00a0\u00b1\u00a01.0\u00a0months, 95% confidence interval 32.3\u201336.5, vs. 33.4\u00a0\u00b1\u00a01.3\u00a0months, 95% confidence interval 30.8\u201336.0,<jats:italic>p\u00a0<\/jats:italic>=\u00a00.045). Univariate analysis revealed a hazard ratio of 0.178 (95% confidence interval 0.029\u20131.075) (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.060) for postoperative<jats:styled-content style=\"fixed-case\">LNG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IUS<\/jats:styled-content>use and endometrioma recurrence. However, for the multivariate regression analysis, only postoperative serum<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\u00a0125 levels were significantly associated with endometrioma recurrence (hazard ratio 1.012,<jats:italic>p\u00a0<\/jats:italic>=\u00a00.010).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Postoperative<jats:styled-content style=\"fixed-case\">LNG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IUS<\/jats:styled-content>use seemed to be comparable to the use of cyclic<jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>in preventing endometrioma recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12294","type":"journal-article","created":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T19:19:31Z","timestamp":1382728771000},"page":"38-44","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Postoperative 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