{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:20:42Z","timestamp":1762323642722},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T00:00:00Z","timestamp":1387324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate expression and localization of prostaglandin receptors <jats:styled-content style=\"fixed-case\">EP<\/jats:styled-content>1\u20104 and <jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content> and localization of stromal factors <jats:styled-content style=\"fixed-case\">CTGF<\/jats:styled-content> (connective tissue growth factor), furin, calgranulin B and <jats:styled-content style=\"fixed-case\">ALOX<\/jats:styled-content>15 (arachidonate 15\u2010lipooxygenase) in human cervical tissue from post\u2010term women with failed or successful labor induction after prostaglandin priming.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Experimental prospective clinical study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary obstetric care center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Twenty\u2010six women giving birth post\u2010term, with failed or successful labor induction, and a control group consisting of 19 women with spontaneous onset of labor and delivery at term.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Biopsies were obtained from post\u2010term women with successful (responders; <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>) and failed (non\u2010responders; <jats:styled-content style=\"fixed-case\">NR<\/jats:styled-content>) labor induction. Women with spontaneous delivery at term were included as controls (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression was determined with real time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>, protein expression and localization with immunohistochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Comparisons of <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> and protein expressions between post\u2010term pregnancies with failed and successful labor induction as well as term controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>EP4 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression was down\u2010regulated concomitant with an up\u2010regulation of EP3 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression in cervix from the <jats:styled-content style=\"fixed-case\">NR<\/jats:styled-content> group as compared with the <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content> group. In stroma, immunoreactivity of the EP4 protein was increased in the <jats:styled-content style=\"fixed-case\">NR<\/jats:styled-content> group as compared with <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Failure of cervical ripening, after local application of prostaglandins for labor induction, may be caused by the increased expression of <jats:styled-content style=\"fixed-case\">EP<\/jats:styled-content>3 and concomitant decrease in <jats:styled-content style=\"fixed-case\">EP<\/jats:styled-content>4 expression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12300","type":"journal-article","created":{"date-parts":[[2013,11,4]],"date-time":"2013-11-04T06:30:57Z","timestamp":1383546657000},"page":"159-167","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The expression of prostaglandin receptors <scp>EP<\/scp>3 and <scp>EP<\/scp>4 in human cervix in post\u2010term pregnancy differs between failed and successful labor induction"],"prefix":"10.1111","volume":"93","author":[{"given":"Nathalie","family":"Roos","sequence":"first","affiliation":[{"name":"Division for Reproductive Endocrinology and the Pediatric Endocrinology Unit Q2:08 Karolinska University Hospital Stockholm Sweden"},{"name":"Division of Obstetrics and Gynecology, H2:01 Department of Women's and Children's Health Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chellakkan 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