{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T11:32:51Z","timestamp":1789903971512,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T00:00:00Z","timestamp":1390867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To examine associations between rheumatoid arthritis (\n                      <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\n                      ) and pregnancy outcomes in first and subsequent births.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Study based on data registered in the Medical Birth Registry of Norway from the period 1 December 1998 to 31 December 2009.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>\n                      Singleton births in women recorded with\n                      <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01496) and reference deliveries from the general population (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0625\u00a0642).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Outcomes of first and subsequent births were analyzed separately. First birth was defined as the first delivery of nulliparous women. Associations between\n                      <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\n                      and maternal and perinatal outcomes were assessed in logistic regression analyses and adjusted for maternal age at delivery, gestational age, smoking habits and for previous cesarean section when relevant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>Maternal and perinatal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Vaginal bleeding was observed more often among women with\n                      <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\n                      both in first pregnancy [adjusted odds ratio (\n                      <jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>\n                      ) 1.8, 95% CI 1.3\u20132.4] and in subsequent pregnancies (\n                      <jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>\n                      1.4, 95% CI 1.1\u20131.9). Elective cesarean section was more common among women with RA both in the first birth (\n                      <jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>\n                      2.0, 95% CI 1.4\u20132.8) and in subsequent births (\n                      <jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>\n                      1.5, 95% CI 1.2\u20132.0). Preterm delivery was more frequent among women with RA than the reference population in first pregnancy (\n                      <jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>\n                      1.5, 95% CI 1.1\u20132.0) and in subsequent pregnancies (\n                      <jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>\n                      1.5, 95% CI 1.1\u20131.9).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Complications and poor pregnancy outcomes were more often observed in women with\n                      <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\n                      and the greatest differences were observed in the first pregnancy.\n                    <\/jats:p>\n                  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Lund Sweden"},{"name":"Department of Laboratory Medicine Women's and Child Health Norwegian University of Science and Technology Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne K.","family":"Daltveit","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care University of Bergen Bergen Norway"},{"name":"Medical Birth Registry of Norway Division of Epidemiology Norwegian Institute of Public Health Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan F.","family":"Skomsvoll","sequence":"additional","affiliation":[{"name":"National Service for Pregnancy and Rheumatic Diseases Department of Rheumatology Trondheim University Hospital Trondheim Norway"},{"name":"Department of Neuroscience Norwegian University of Science and Technology Trondheim 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