{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:11:11Z","timestamp":1791976271228,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T00:00:00Z","timestamp":1392768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2014,3]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n \n To evaluate ultrasonography and magnetic resonance imaging (\n MRI<\/jats:styled-content>\n ) performance in differentiating benign leiomyomas from malignant mesenchymal or mixed tumors (\n MMT<\/jats:styled-content>\n ) and smooth muscle tumors of uncertain malignant potential of the uterus (\n STUMP<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Retrospective cohort study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n University hospital, France.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n \n One hundred and eight women who underwent imaging before surgery for uterine mesenchymal tumor (85 with benign leiomyomas and 23 with\n MMT<\/jats:styled-content>\n \/\n STUMP<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The ultrasonography reports were reviewed. Conventional, perfusion and diffusion\n MRI<\/jats:styled-content>\n were blindly analyzed. Recursive partitioning analysis (\n RPA<\/jats:styled-content>\n ) was performed to construct diagnostic flowcharts.\n <\/jats:p>\n <\/jats:sec>\n \n Main outcome measures<\/jats:title>\n Accuracy of a diagnostic flowchart.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n At ultrasonography, single tumor, non\u2010myometrial origin, absence of acoustic shadowing, thickened endometrium and ascites were associated with\n MMT<\/jats:styled-content>\n \/\n STUMP<\/jats:styled-content>\n (\n p\u00a0<\/jats:italic>\n =\u00a00.001,\n p\u00a0<\/jats:italic>\n <\u00a00.001,\n p\u00a0<\/jats:italic>\n =\u00a00.03,\n p<\/jats:italic>\n \u00a0<\u00a00.0001 and\n p\u00a0<\/jats:italic>\n =\u00a00.03, respectively). For conventional\n MRI<\/jats:styled-content>\n , single tumor, non\u2010myometrial origin, large tumor, poorly defined margins, thickened endometrium, peritoneal implants, intermediate or high signal intensity in T1 or T2 sequences, heterogeneous T1 signal, cystic alteration of the tumor and heterogeneity of the tumor's enhancement were significantly associated with\n MMT<\/jats:styled-content>\n \/\n STUMP<\/jats:styled-content>\n . Perfusion weighted imaging and perfusion curve types were not discriminant. For diffusion weighted imaging, a high signal intensity at b\u00a0=\u00a01000\u00a0s\/mm\u00b2 was associated with\n MMT<\/jats:styled-content>\n \/\n STUMP<\/jats:styled-content>\n (\n p<\/jats:italic>\n \u00a0<\u00a00.001).\n RPA<\/jats:styled-content>\n resulted in a model that ultimately included age, number of tumors and the aspect of the endometrium (both evaluated by\n MRI<\/jats:styled-content>\n ) and that had an area under the curve of 0.95.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Simple criteria, such as single tumor, non\u2010myometrial tumor, abnormal endometrium and age, should question the diagnosis of benign leiomyoma.\n MRI<\/jats:styled-content>\n enhanced the sensitivity of detecting\n MMT<\/jats:styled-content>\n \/\n STUMP<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/aogs.12325","type":"journal-article","created":{"date-parts":[[2013,12,27]],"date-time":"2013-12-27T09:04:39Z","timestamp":1388135079000},"page":"261-268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Value of ultrasonography and magnetic resonance imaging for the characterization of uterine mesenchymal tumors"],"prefix":"10.1111","volume":"93","author":[{"given":"Claire","family":"Bonneau","sequence":"first","affiliation":[{"name":"Department of Gynecology\u2010Obstetrics University Hospitals of Paris\u2010Est H\u00f4pital Tenon University Pierre and Marie Curie Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Thomassin\u2010Naggara","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospitals of Paris\u2010Est H\u00f4pital Tenon University Pierre and Marie Curie Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Dechoux","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospitals of Paris\u2010Est H\u00f4pital Tenon University Pierre and Marie Curie Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Cortez","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospitals of Paris\u2010Est H\u00f4pital Tenon University Pierre and Marie Curie Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9mile","family":"Darai","sequence":"additional","affiliation":[{"name":"Department of Gynecology\u2010Obstetrics University Hospitals of Paris\u2010Est H\u00f4pital Tenon University Pierre and Marie Curie Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Rouzier","sequence":"additional","affiliation":[{"name":"Department of Gynecology\u2010Obstetrics University Hospitals of Paris\u2010Est H\u00f4pital Tenon University Pierre and Marie Curie Paris France"},{"name":"Department of Surgery Curie Institute University of Versailles\u2010Saint\u2010Quentin\u2010en\u2010Yvelines Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,19]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"47","article-title":"Classifying, staging, and treating uterine sarcomas","volume":"18","author":"Forney J","year":"1981","journal-title":"Contemp Obstet Gynec"},{"key":"e_1_2_9_3_1","first-page":"218","volume-title":"Pathology and genetics of tumours of the breast and female genital organs","author":"Hendrickson M","year":"2003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-8258(03)00207-5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70226-8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.236035033"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2011.07.002"},{"key":"e_1_2_9_8_1","first-page":"414","article-title":"Uterine sarcoma in patients operated on for presumed leiomyoma and rapidly growing leiomyoma","volume":"83","author":"Parker WH","year":"1994","journal-title":"Obstet Gynecol"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)45789-4"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10100751"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.09020101.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(89)90065-6"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.10030220.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.177.6.1771307"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.173.3.10470920"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2005.12.032"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2006.09.006"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20626"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-009-1471-x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-007-0787-7"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faogs.12325","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.12325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:35:11Z","timestamp":1695476111000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.12325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,19]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/aogs.12325"],"URL":"https:\/\/doi.org\/10.1111\/aogs.12325","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,19]]},"assertion":[{"value":"2013-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-12-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-02-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}