{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:51:35Z","timestamp":1790736695040,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T00:00:00Z","timestamp":1392768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare perinatal singleton and multiple outcomes in a large Dutch in vitro fertilization (<jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>)\/intracytoplasmic sperm injection (<jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content>) population and within risk subgroups. Newborns were assigned to a risk category based on gestational age, birthweight, Apgar score and congenital malformation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Register\u2010based retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Netherlands Perinatal Registry data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Sample<\/jats:title><jats:p>A total of 3041 singletons and 1788 multiple children born from <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> in 2003\u20132005.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Student's <jats:italic>t<\/jats:italic>\u2010test or Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test was used to analyze continuous data, chi\u2010squared analyses were used for categorical data. Multivariate logistic and linear regression analysis was performed to analyze whether the risk stratification criteria were associated with neonatal hospital admission and length of stay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Start of labor, mode of delivery, gestational age, birthweight, 5\u2010min Apgar score, congenital malformation, neonatal hospital admission, neonatal intensive care unit admission and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content>\u2010conceived multiples had considerably poorer outcomes than singletons in terms of cesarean section rate, preterm birth, birthweight, being small\u2010for\u2010gestational\u2010age, Apgar score, neonatal hospital admission, neonatal intensive care unit admission and neonatal mortality. As opposed to the results found in the total study population and the low\u2010risk and moderate\u2010risk populations, high\u2010risk multiples showed better outcomes than high\u2010risk singletons regarding cesarean section rate, birthweight and Apgar score. All risk stratification variables were associated with being hospitalized after birth. Length of stay was associated with all risk stratification criteria except Apgar score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Perinatal outcomes in <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content>\u2010conceived multiples are considerably poorer than in singletons. This finding mainly pertains to low\u2010risk children. High\u2010risk multiples had significantly better perinatal outcomes than high\u2010risk singletons.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12328","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T12:38:23Z","timestamp":1389184703000},"page":"277-286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["A comparison of perinatal outcomes in singletons and multiples born after in vitro fertilization or intracytoplasmic sperm injection stratified for neonatal risk criteria"],"prefix":"10.1111","volume":"93","author":[{"given":"Mirjam M.J.","family":"van Heesch","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology and Medical Technology Assessment Maastricht University Medical Center Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes 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