{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:49:01Z","timestamp":1778795341336,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,23]],"date-time":"2014-03-23T00:00:00Z","timestamp":1395532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>As the patterns and frequency of maternal and clinical conditions and outcomes and gross and histological placental features and lesions vary with gestational age at delivery, we aimed to study the impact of these changes on the placental diagnosis, hoping to uncover potential novel clusters of gestational age\u2010associated clinical and pathological diagnoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective statistical analysis of clinicoplacental database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>We analyzed 28 clinical (maternal and fetal) and 49 gross and microscopic placental variables from 3294 consecutively signed placentas received between 2001 and 2012, divided into three gestational age groups: 16\u201327\u00a0weeks, 697 cases; 28\u201336\u00a0weeks, 1365 cases; and 37+\u00a0weeks, in all 1232 cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Classical statistics by chi\u2010squared and Fischer's tests, and the Ward agglomerative hierarchical clustering and multidimensional scaling techniques, were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The placental phenotypes clustered statistically significantly with severe preeclampsia in the second trimester; preterm premature rupture of membranes, placental abruption, and fetal growth restriction in the whole third trimester; and abnormally invasive placenta, thick meconium, maternal diabetes mellitus, and substance abuse in term pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The applied statistical analyses made it possible to simultaneously compare the strength of clinicoplacental associations separately in three pregnancy intervals. Placental clinicopathological associations are strongest for the second trimester, i.e. severe preeclampsia and preterm ascending infection\u2010related conditions, but were not significant for other pregnancy complications such as mild preeclampsia, chronic hypertension, diabetes mellitus, or umbilical cord compromise.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12350","type":"journal-article","created":{"date-parts":[[2014,2,8]],"date-time":"2014-02-08T15:12:44Z","timestamp":1391872364000},"page":"392-398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Clinicoplacental phenotypes vary with gestational age: an analysis by classical and clustering methods"],"prefix":"10.1111","volume":"93","author":[{"given":"Jerzy","family":"Stanek","sequence":"first","affiliation":[{"name":"Division of Pathology and Laboratory Medicine Department of Pediatrics University of Cincinnati Medical Center Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Biesiada","sequence":"additional","affiliation":[{"name":"Division of Biomedical Informatics Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martyna","family":"Trzeszcz","sequence":"additional","affiliation":[{"name":"Department of Pathology and Oncological Cytology Medical University of Wroc\u0142aw Wroc\u0142aw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,23]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Williams Obstetrics","author":"Cunningham FG","year":"2005"},{"key":"e_1_2_8_3_1","volume-title":"Pathology of the human placenta","author":"Benirschke K","year":"2006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0002-9378(03)00576-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/b138589"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.03.025"},{"key":"e_1_2_8_7_1","first-page":"449","article-title":"Practice guideline for examination of the placenta","volume":"121","author":"Langston C","year":"1997","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","DOI":"10.55418\/1881041891","volume-title":"Placental pathology","author":"Kraus FT","year":"2004"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2011-0645-RA"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2013-0219"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.12.048"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6874-9-21"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2011.01023.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.10.865"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.10.866"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031819"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.704450"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2011.03.006"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2012.04.013"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/15513815.2012.659391"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767050903334885"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm.2011.098"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2004.00071.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/014436105400041396"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2012.09.013"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3872"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.2350\/11-12-1127-OA.1"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.4236\/ojog.2013.39A002"},{"key":"e_1_2_8_29_1","first-page":"585","article-title":"Estimating the time of death in stillborn foetuses: II. 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