{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T15:55:30Z","timestamp":1720194930335},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T00:00:00Z","timestamp":1398211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate risk factors for maternal mortality among <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected women in Tanzania.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> care and treatment clinics in Dar es Salaam, Tanzania.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected pregnant women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were collected for all patients enrolled in an <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content> care and treatment program. Between November 2004 and September 2011, there were 18\u00a0917 women pregnant at least once during the follow\u2010up. Thirteen percent of these women had more than one pregnancy, with 21\u00a0645 pregnancies occurring. Logistic regression was used to explore the predictors of maternal death among these women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Maternal mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period, 363 maternal deaths occurred, giving a maternal mortality ratio of 1729 [95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 1553\u20131905] per 100\u00a0000 live births. Being wasted [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 3.38, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.58\u20134.45] or anemic (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.26, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.70\u20133.00) was associated with a higher risk of maternal mortality. Women who were initiated on antiretroviral therapy before their pregnancy had a 55% decreased risk of maternal mortality (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.29\u20130.70) compared with women who were not. The risk of maternal mortality decreased with the length of time on antiretroviral therapy during pregnancy, by 8% for each additional month (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.92, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.88\u20130.96).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Maternal mortality was high among <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected women. Initiating women on antiretroviral therapy as early as possible and providing nutritional interventions during pregnancy should be considered as means to reduce the maternal mortality among these women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12374","type":"journal-article","created":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T13:26:44Z","timestamp":1394544404000},"page":"463-468","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Maternal mortality among <scp>HIV<\/scp>\u2010infected pregnant women in Tanzania"],"prefix":"10.1111","volume":"93","author":[{"given":"Nan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Global Health and Population Harvard School of Public Health Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Matchi","sequence":"additional","affiliation":[{"name":"Management and Development for Health 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