{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:17Z","timestamp":1787013857617,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T00:00:00Z","timestamp":1398124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2014,7]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n \n To compare tumor characteristics and clinical outcome of patients with cervical locally advanced adenocarcinoma (\n AC<\/jats:styled-content>\n )\/adenosquamous carcinoma (\n ASC<\/jats:styled-content>\n ) and squamous cell carcinoma (\n SCC<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Retrospective study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n National Taiwan University Hospital, Taipei, Taiwan.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n \n All patients with cervical\n SCC<\/jats:styled-content>\n (\n n\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 35),\n AC<\/jats:styled-content>\n or\n ASC<\/jats:styled-content>\n (\n n\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 194) with FIGO stage \u2265IIB who received definitive radiotherapy or concurrent chemoradiotherapy (\n CCRT<\/jats:styled-content>\n ) from January 1995 to December 2009.\n <\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n Medical and histopathological record review.<\/jats:p>\n <\/jats:sec>\n \n Main outcome measures<\/jats:title>\n \n Progression\u2010free survival (\n PFS<\/jats:styled-content>\n ), local recurrence\u2010free survival, distant metastasis\u2010free survival, and overall survival (\n OS<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Compared with the\n SCC<\/jats:styled-content>\n subgroup, patients with\n AC<\/jats:styled-content>\n \/\n ASC<\/jats:styled-content>\n were significantly younger (\n p\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.007), more of them without clinical symptoms were diagnosed by abnormal Pap smear findings (\n p\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.043), and less responded to treatment (\n p\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.018). After a median follow\u2010up of 59.3\u00a0months, patients with\n AC<\/jats:styled-content>\n \/\n ASC<\/jats:styled-content>\n had worse 5\u2010year\n PFS<\/jats:styled-content>\n (30.0% vs. 47.6%,\n p\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.044), worse 5\u2010year distant metastasis\u2010free survival (41.5% vs. 69.9%,\n p\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.005), and trends toward worse 5\u2010year local recurrence\u2010free survival (64.4% vs. 76.2%,\n p\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.165) and worse 5\u2010year\n OS<\/jats:styled-content>\n (41.3% vs. 58.1%,\n p\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.090) than patients with\n SCC<\/jats:styled-content>\n . In univariate analysis, early\n FIGO<\/jats:styled-content>\n stage and complete treatment response were significantly associated with\n PFS<\/jats:styled-content>\n and\n OS<\/jats:styled-content>\n . Histology of non\u2010\n AC<\/jats:styled-content>\n \/\n ASC<\/jats:styled-content>\n and Point A biologically equivalent doses in 2\u2010Gy fractions >85\u00a0Gy were significantly associated with better\n PFS<\/jats:styled-content>\n , and\n CCRT<\/jats:styled-content>\n was significantly associated with better\n OS<\/jats:styled-content>\n . In multivariate analysis, complete treatment response and early\n FIGO<\/jats:styled-content>\n stage remained significant factors for predicting better\n PFS<\/jats:styled-content>\n and\n OS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Cervical\n AC<\/jats:styled-content>\n \/\n ASC<\/jats:styled-content>\n may be more aggressive than is\n SCC<\/jats:styled-content>\n . For cervical\n AC<\/jats:styled-content>\n \/\n ASC<\/jats:styled-content>\n , more comprehensively effective treatments are warranted.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/aogs.12383","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T05:35:39Z","timestamp":1395725739000},"page":"661-668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Differential clinical characteristics, treatment response and prognosis of locally advanced adenocarcinoma\/adenosquamous carcinoma and squamous cell carcinoma of cervix treated with definitive radiotherapy"],"prefix":"10.1111","volume":"93","author":[{"given":"Jenny Ling\u2010Yu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Oncology National Taiwan University Hospital Yun Lin Branch Yun\u2010Lin Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Yuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Oncology National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Sen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging National Taiwan University Hospital Yun Lin Branch Yun\u2010Lin Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruey\u2010Jien","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology National Taiwan University 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