{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T04:52:18Z","timestamp":1780807938981,"version":"3.54.1"},"reference-count":7,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,4,25]],"date-time":"2014-04-25T00:00:00Z","timestamp":1398384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether \u201cneonatal intensive care unit (<jats:styled-content style=\"fixed-case\">NICU<\/jats:styled-content>) admission\u201d is a valid surrogate outcome measure to assess neonatal condition in clinical studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary hospital in the Netherlands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Neonates admitted to <jats:styled-content style=\"fixed-case\">NICU<\/jats:styled-content> during a 10\u2010year period. Inclusion was restricted to singletons born beyond 37\u00a0weeks of gestation, and admitted to <jats:styled-content style=\"fixed-case\">NICU<\/jats:styled-content> in the first 24\u00a0h for delivery\u2010related morbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patient characteristics and admission data were compared for four groups based on the line of care during delivery, i.e. home birth (Ia), midwife\u2010led hospital delivery (Ib), secondary care (<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>), tertiary care (<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Percentage of neonates\/infants that died during <jats:styled-content style=\"fixed-case\">NICU<\/jats:styled-content> admission, diagnosis on admission, treatment received and a Neonatal Therapeutic Intervention Score System (<jats:styled-content style=\"fixed-case\">NTISS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We studied 776 newborns (Ia 52, Ib 25, <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> 160, <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> 512, 27 unknown). The mortality rate differed significantly (Ia 15%, Ib 12%, <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> 22%, <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> 1%, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.01), as did the <jats:styled-content style=\"fixed-case\">NTISS<\/jats:styled-content> morbidity scores at admission [Ia 12.0 (6.0\u201323.0), Ib 8.5 (6.3\u201310.0), <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> 21.0 (15.0\u201330.0), <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> 6.0 (4.0\u20139.0); <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01], diagnosis at admission, received treatment and the duration of admission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The severity of neonatal illness after 37\u00a0weeks of gestation differed depending on the line of care in which they were born, with neonates born in secondary care consistently having the highest morbidity, and those born in tertiary care having the lowest. <jats:styled-content style=\"fixed-case\">NICU<\/jats:styled-content> admission should not be used as an outcome measure for neonatal morbidity, specifically not when comparing different birth settings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12384","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T09:35:39Z","timestamp":1395740139000},"page":"603-609","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The validity of the variable \u201c<scp>NICU<\/scp> admission\u201d as an outcome measure for neonatal morbidity: a retrospective study"],"prefix":"10.1111","volume":"93","author":[{"given":"Melanie M.J.","family":"Wiegerinck","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Academic Medical Center Amsterdam the Netherlands"},{"name":"Department of Obstetrics and Gynecology Onze Lieve Vrouwe Gasthuis Hospital Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora A.","family":"Danhof","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Academic Medical Center Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton H.","family":"Van Kaam","sequence":"additional","affiliation":[{"name":"Department of Neonatology Emma Children's Hospital Academic Medical Center Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Tamminga","sequence":"additional","affiliation":[{"name":"Department of Neonatology Emma Children's Hospital Academic Medical Center Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben Willem J.","family":"Mol","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Academic Medical Center Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c5639"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-197403000-00001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198301000-00001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1542\/peds.90.4.561","article-title":"Neonatal therapeutic intervention scoring system: a therapy\u2010based severity\u2010of\u2010illness index","volume":"90","author":"Gray JE","year":"1992","journal-title":"Pediatrics"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2012.03576.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70516-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.2003.019109"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faogs.12384","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.12384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T21:01:52Z","timestamp":1694638912000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.12384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,25]]},"references-count":7,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/aogs.12384"],"URL":"https:\/\/doi.org\/10.1111\/aogs.12384","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,25]]},"assertion":[{"value":"2013-10-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-04-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}