{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T11:17:30Z","timestamp":1775647050327,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T00:00:00Z","timestamp":1403222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001734","name":"University of Copenhagen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007403","name":"Dagmar Marshalls Fond","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007403","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ivan Nielsens Fond For Personer Med Specielle Sindslidelser"},{"name":"Region Sj\u00ef\u00bf\u00bdllands Sundhedsvidenskabelige Forskningsfond"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To test if serum <jats:styled-content style=\"fixed-case\">YKL<\/jats:styled-content>\u201040 is increased in women developing preeclampsia or small\u2010for\u2010gestational age fetuses. We also assessed the association between uterine artery pulsatility index, notching and serum <jats:styled-content style=\"fixed-case\">YKL<\/jats:styled-content>\u201040 levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>A primary referral unit for obstetric ultrasound.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 1214 unselected pregnant women enrolled at nuchal translucency examination between 11<jats:sup>+3<\/jats:sup> and 13<jats:sup>+6<\/jats:sup>\u00a0weeks of gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All women had ultrasound and blood sample collection at the nuchal translucency scan, a 20\u2010week malformation scan and 25\u2010week and 32\u2010week fetal growth examinations. Uterine artery Doppler was assessed and outcome was registered from medical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Preeclampsia, hypertension, small\u2010for\u2010gestational age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum <jats:styled-content style=\"fixed-case\">YKL<\/jats:styled-content>\u201040 was associated with increasing maternal age (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.0001), body mass index (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.0002), primiparity (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.0003), and hypertension (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.015). Serum <jats:styled-content style=\"fixed-case\">YKL<\/jats:styled-content>\u201040 increased from 12 to 20\u00a0weeks and decreased from 20\u201325 and 25\u201332\u00a0weeks of gestation. No association was found between preeclampsia and serum <jats:styled-content style=\"fixed-case\">YKL<\/jats:styled-content>\u201040. Small\u2010for\u2010gestational\u2010age at birth was significantly associated with a 5.4% increase in serum <jats:styled-content style=\"fixed-case\">YKL<\/jats:styled-content>\u201040 at 32\u00a0weeks of gestation (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.5\u20139.3, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.005). An association was found between uterine artery pulsatility index at 32\u00a0weeks and small\u2010for\u2010gestational age (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.0015) but not between <jats:styled-content style=\"fixed-case\">YKL<\/jats:styled-content>\u201040 and uterine artery notching (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.83).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum <jats:styled-content style=\"fixed-case\">YKL<\/jats:styled-content>\u201040 was not associated with preeclampsia. Increasing serum <jats:styled-content style=\"fixed-case\">YKL<\/jats:styled-content>\u201040 was related to maternal age, body mass index and small\u2010for\u2010gestational age and may reflect an exaggerated inflammatory response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12432","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T11:29:40Z","timestamp":1400844580000},"page":"817-824","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Serum <scp>YKL<\/scp>\u201040 and uterine artery Doppler \u2013 a prospective cohort study, with focus on preeclampsia and small\u2010for\u2010gestational\u2010age"],"prefix":"10.1111","volume":"93","author":[{"given":"Dorte","family":"Gybel\u2010Brask","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Roskilde University Hospital Roskilde Denmark"},{"name":"Molecular Unit Department of Pathology Copenhagen University Hospital Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estrid","family":"H\u00f8gdall","sequence":"additional","affiliation":[{"name":"Molecular Unit Department of Pathology Copenhagen University Hospital Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Johansen","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Oncology Copenhagen University Hospital Herlev Denmark"},{"name":"Faculty of Medicine and Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ib Jarle","family":"Christensen","sequence":"additional","affiliation":[{"name":"The Finsen Laboratory Rigshospitalet and Biotech Research and Innovation Centre (BRIC) University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lillian","family":"Skibsted","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Roskilde University Hospital Roskilde Denmark"},{"name":"Faculty of Medicine and Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-012110-142250"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.09.66"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1369\/0022155411433331"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.7A7245.2007"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.212514"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2011.03.014"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-10-0868"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.07.032"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2011.01.007"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb14164.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.08.055"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2010.11.022"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.070430"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7628"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2007.09.033"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2008.10.003"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-6175.2007.06695.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.1.150"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365510050184886"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2012.03.003"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2005.02.020"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.146530"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-006-0076-y"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.107607"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2009.04.004"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.03.027"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e2635"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/jmf.12.2.78.88"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5315"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faogs.12432","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.12432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:00:51Z","timestamp":1695567651000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.12432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,20]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/aogs.12432"],"URL":"https:\/\/doi.org\/10.1111\/aogs.12432","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,20]]},"assertion":[{"value":"2013-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-05-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-06-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}