{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:24:41Z","timestamp":1767165881718,"version":"build-2238731810"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T00:00:00Z","timestamp":1411430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Key Technologies Research and Development Program of Shaanxi Province","award":["2012K17-02-06"],"award-info":[{"award-number":["2012K17-02-06"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81270697"],"award-info":[{"award-number":["81270697"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Scientific Research Program Funded by Shaanxi Provincial Education Department","award":["11jk0713"],"award-info":[{"award-number":["11jk0713"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To examine the expression of\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      200 and its receptor (\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      200R) in human chorionic villi during the first trimester of normal pregnancy and early spontaneous abortion (\n                      <jats:styled-content style=\"fixed-case\">ESA<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Expression of\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      200 and\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      200R in the chorionic villi was determined using streptavidin\u2010peroxidase immunohistochemistry, confocal laser scanning microscopy and real\u2010time polymerase chain reaction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010five women diagnosed with\n                      <jats:styled-content style=\"fixed-case\">ESA<\/jats:styled-content>\n                      and 30 women experiencing a healthy pregnancy in a medical university hospital in China were enrolled in this study between 2011 and 2013.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      200 and\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      200R expression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The expression of\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      200 in syncytiotrophoblast cells was significantly higher during normal pregnancy than in\n                      <jats:styled-content style=\"fixed-case\">ESA<\/jats:styled-content>\n                      (0.51\u00a0\u00b1\u00a00.05 vs. 0.35\u00a0\u00b1\u00a00.05). In contrast, expression of\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      200 in cytotrophoblast cells and\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      200R in stromal cells was significantly lower during normal pregnancy when compared with\n                      <jats:styled-content style=\"fixed-case\">ESA<\/jats:styled-content>\n                      (\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      200: 0.16\u00a0\u00b1\u00a00.02 vs. 0.32\u00a0\u00b1\u00a00.03;\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      200R: 0.19\u00a0\u00b1\u00a00.03 vs. 0.22\u00a0\u00b1\u00a00.02). In villi, the expression of both\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      200 protein and\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      200R transcripts were significantly higher in healthy first\u2010trimester pregnancy than in\n                      <jats:styled-content style=\"fixed-case\">ESA<\/jats:styled-content>\n                      (\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      200: 156.89\u00a0\u00b1\u00a0105.65 vs. 37.51\u00a0\u00b1\u00a017.62).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      There is an increase in inhibitory properties of human chorionic villi during normal pregnancy. The mechanism underlying\n                      <jats:styled-content style=\"fixed-case\">ESA<\/jats:styled-content>\n                      might be associated with enhanced expression of\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      200 and\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      200R in the trophoblast, leading to an upregulation of the immune response during the first trimester of pregnancy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.12476","type":"journal-article","created":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T11:43:27Z","timestamp":1408621407000},"page":"1248-1254","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Reduced\n                    <scp>CD<\/scp>\n                    200 and\n                    <scp>CD<\/scp>\n                    200R1 expression in human chorionic villi contributes to early spontaneous abortion"],"prefix":"10.1111","volume":"93","author":[{"given":"Li\u2010Qin","family":"Wang","sequence":"first","affiliation":[{"name":"Fourth Hospital of Xi'an Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Fang","family":"Yan","sequence":"additional","affiliation":[{"name":"The First People's Hospital of Baiyin City Baiyin Gansu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Prevention and Health First Affiliated Hospital of Medical School Xi'an Jiaotong University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Chu","sequence":"additional","affiliation":[{"name":"Fourth Hospital of Xi'an Xi'an 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