{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T15:15:28Z","timestamp":1770995728822,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T00:00:00Z","timestamp":1411430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Helsinki University Research Grants"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We evaluated whether phosphorylated insulin\u2010like growth factor binding protein\u20101 (ph<jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101) in blood or from other sources interferes with the vaginal <jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101 dipstick test in rupture of fetal membranes (<jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Antenatal Clinic, University Hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 247 pregnant women consulting the emergency obstetric unit with self\u2010reported amniotic fluid leakage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Vaginal samples were tested with the <jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101 dipstick test and the concentrations of different <jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101 isoforms were measured by two immunoenzymometric assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measure<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101 dipstick test result in the presence or absence of blood and different phosphoisoforms of <jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The dipstick test was positive in 37.2% of women and negative in 62.8% of women. Vaginal bleeding was present in 19.4%. In women with a positive test and clinical evidence of <jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content>, both <jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101 and ph<jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101 concentrations in vaginal fluid were lower in women with than in women without bleeding (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.025 and <jats:italic>p\u00a0<\/jats:italic>=\u00a00.031, respectively). No difference was found in concentrations of <jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101 and ph<jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101 in women with a positive dipstick test without <jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content>, with or without vaginal bleeding. In women with a negative test the concentrations of <jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101 and ph<jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101 remained below the cut\u2010off for the test, regardless of bleeding. <jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101 concentration did not differ by cervical status, but ph<jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101 concentration was higher in women with a ripe cervix (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Rapid vaginal dipstick test can be used in the detection of <jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content> irrespective of the presence or absence of blood. Positive tests near term indicate either <jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content> or leakage of less ph<jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101 associated with onset of delivery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12481","type":"journal-article","created":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T15:44:35Z","timestamp":1408635875000},"page":"1282-1289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Usefulness of the insulin\u2010like growth factor binding protein\u20101 bedside test for ruptured fetal membranes"],"prefix":"10.1111","volume":"93","author":[{"given":"Hanna","family":"Kallioniemi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University Central Hospital Helsinki 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