{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T12:46:31Z","timestamp":1753274791485},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,9,21]],"date-time":"2014-09-21T00:00:00Z","timestamp":1411257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To establish reference intervals for cancer antigen 125 (<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\u2010125) in women with expected normal pregnancy, delivery, and early postpartum period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Department of Clinical Biochemistry and Obstetrics, Copenhagen University Hospital, Gentofte, Denmark.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Eight hundred and one women with expected normal pregnancies were investigated. Of these, 640 delivered vaginally, 82 by emergency cesarean section, and 79 by elective cesarean section; 720 women had uncomplicated pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Samples were collected at gestational weeks 13\u201320, 21\u201328, 29\u201334, 35\u201342, during labor, and on first and second day postpartum. Reference intervals were calculated for each gestational period as recommended by the International Federation of Clinical Chemistry and Laboratory Medicine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Concentration of serum <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\u2010125 during the gestational period and around delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CA\u2010125 was fairly stable below 35\u00a0U\/mL during pregnancy but increased markedly during vaginal delivery, to a minor degree during emergency cesarean section, and only slightly during elective cesarean section. In the early postpartum period, CA\u2010125 decreased with an apparent half\u2010life of 24\u00a0h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The CA\u2010125 cut\u2010off value (&lt;35\u00a0U\/mL) used for non\u2010pregnant women can be used for women during pregnancy after gestational week 13 as a supplement to ultrasound evaluation of ovarian cysts. The wide range of CA\u2010125 concentration during normal pregnancies makes it unlikely that small fluctuations in CA\u2010125 can be clinically useful for identifying other conditions. Measuring CA\u2010125 around the time of delivery is not recommended. Gestational age\u2010specific reference intervals during normal pregnancy are not needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12492","type":"journal-article","created":{"date-parts":[[2014,8,30]],"date-time":"2014-08-30T08:35:26Z","timestamp":1409387726000},"page":"1295-1301","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Cancer antigen 125 after delivery in women with a normal pregnancy: a prospective cohort study"],"prefix":"10.1111","volume":"93","author":[{"given":"Pal B.","family":"Szecsi","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry Copenhagen University Hospital Gentofte Hellerup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malene R.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Copenhagen University Hospital Gentofte Hellerup, 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