{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:43:38Z","timestamp":1782171818044,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T00:00:00Z","timestamp":1412035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Early\u2010onset preeclampsia is associated with premature cardiovascular disease. We previously demonstrated that femoral intima\u2013media thickness (<jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content>) and markers of cardiovascular disease were increased in women 1\u00a0year after early\u2010onset preeclampsia. The current study measured (progression of) <jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content>, cardiovascular disease risk factors and markers of endothelial cell dysfunction 4\u20135\u00a0years postpartum in the same women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Case\u2013control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Formerly preeclamptic women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content> of carotid and femoral arteries was measured by ultrasound, as a marker of subclinical atherosclerosis. Various conventional cardiovascular risk factors were determined, as well as serum markers of endothelial cell activation and inflammation. Values were compared with those 1\u00a0year after the first (preeclamptic) pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 17 formerly preeclamptic women (cases) and 16 controls. Mean interval between index delivery and day of investigation was 4.7\u00a0years for the cases and 4.3\u00a0years for the controls. Neither differences nor progression of <jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content> was observed between the cases and the controls. Increased blood pressure, body mass index, serum triglycerides and inflammatory markers were found in the cases compared with the controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content> was not increased in women with an almost 5\u2010year history of severe preeclampsia as an indicator of increased cardiovascular risk. This study suggests a transient adaptive response of the arteries in formerly preeclamptic women. The persistence of cardiovascular risk factors in this group emphasizes the need for long\u2010term follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12499","type":"journal-article","created":{"date-parts":[[2014,9,9]],"date-time":"2014-09-09T07:39:31Z","timestamp":1410248371000},"page":"1309-1316","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Follow up of intima\u2013media thickness after severe early\u2010onset preeclampsia"],"prefix":"10.1111","volume":"93","author":[{"given":"Judith","family":"Blaauw","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Groningen and University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban T.D.","family":"Souwer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Groningen and University Medical 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