{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:38:14Z","timestamp":1789180694503,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,19]],"date-time":"2014-10-19T00:00:00Z","timestamp":1413676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"TGPSH"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the efficacy of a single prophylactic dose of ampicillin combined with metronidazole to prevent postcesarean section infections compared with a multiple day regimen in low\u2010resource settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>An evaluator\u2010blinded randomized, controlled, noninferiority trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Two rural hospitals in Tanzania.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Of 181 enrolled eligible women with an indication for cesarean section, information on 176 was analyzed by intention\u2010to\u2010treat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The women were randomly assigned to either the intervention group who received a single dose of ampicillin and metronidazole, or to the control group who received a multiple\u2010day regimen of ampicillin\/amoxicillin and metronidazole.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The primary outcome was maternal postcesarean infection. Secondary outcomes were severity of these infections, other maternal complications, and the duration of hospital stay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the intervention group (<jats:italic>n<\/jats:italic>\u00a0=\u00a089), six women (6.7%) developed a wound infection compared with nine (10.3%) in the control group (<jats:italic>n<\/jats:italic>\u00a0=\u00a087) (difference 3.60; 95% CI \u22124.65 to 11.85) (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.40).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A single dose of prophylactic ampicillin and metronidazole is equally effective as a multiple\u2010day regimen in preventing postcesarean wound infections in low\u2010resource settings, therefore it can be considered as a good strategy in low\u2010resource settings. The reduced quantity of prophylactic antibiotics will reduce costs without increasing the risk of maternal infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12517","type":"journal-article","created":{"date-parts":[[2014,9,29]],"date-time":"2014-09-29T10:14:19Z","timestamp":1411985659000},"page":"43-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Single\u2010dose compared with multiple day antibiotic prophylaxis for cesarean section in low\u2010resource settings, a randomized controlled, noninferiority trial"],"prefix":"10.1111","volume":"94","author":[{"given":"Esther H.M.N.","family":"Westen","sequence":"first","affiliation":[{"name":"Mkomaindo District Hospital Masasi Tanzania"},{"name":"Department of Obstetrics and Gynecology M\u00e1xima Medical Center Veldhoven the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal 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