{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:49:58Z","timestamp":1760906998125,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,12,25]],"date-time":"2014-12-25T00:00:00Z","timestamp":1419465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004756","name":"Emil Aaltonen Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004756","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Finska L\u00c3\u00a4kares\u00c3\u00a4llskapet"},{"DOI":"10.13039\/501100007083","name":"Orion Farmos Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007083","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008484","name":"Paavo Nurmi Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008484","id-type":"DOI","asserted-by":"crossref"}]},{"name":"P\u00c3\u00a4ivikki and Sakari Sohlberg foundation"},{"name":"the Finnish Medical Foundation"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the possible association between menopausal hot flushes and bone mineral density.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Healthy women (<jats:italic>n<\/jats:italic>\u00a0=\u00a0143) with or without hot flushes, 6\u201336\u00a0months postmenopausal after participating in a 6\u2010month hormone therapy trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The women prospectively recorded the number and severity of hot flushes for 2\u00a0weeks. Bone mineral density in lumbar and hip bones was measured with dual\u2010energy X\u2010ray absorptiometry at recruitment and reassessed in 114 women approximately 6.2\u00a0years later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Hot flushes and bone mineral density.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At recruitment, hot flushes were absent in 22 women, mild in 32, moderate in 28, and severe in 61. Lumbar bone mineral densities in non\u2010flushing women (1.130\u00a0\u00b1\u00a00.022\u00a0g\/cm<jats:sup>2<\/jats:sup>; mean\u00a0\u00b1 SEM), and in those with mild (1.088\u00a0\u00b1\u00a00.024\u00a0g\/cm<jats:sup>2<\/jats:sup>), moderate (1.082\u00a0\u00b1 0.030\u00a0g\/cm<jats:sup>2<\/jats:sup>) or severe (1.102\u00a0\u00b1\u00a00.019\u00a0g\/cm<jats:sup>2<\/jats:sup>) hot flushes did not differ, nor were there differences in hip bone mineral densities between the four study groups. During the follow\u2010up, lumbar bone mineral density decreased by a mean of 0.4\u00a0\u00b1\u00a00.1% a year in women not using hormone therapy, and increased by 0.1\u00a0\u00b1\u00a00.2% a year in hormone therapy users (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.019). The respective non\u2010significant changes in left and right total hip bone mineral densities were \u2013 \u22120.6\u00a0\u00b1\u00a00.01 and \u22121.0\u00a0\u00b1\u00a00.1 for the non\u2010users, and \u22120.4\u00a0\u00b1\u00a00.1 and \u22120.6\u00a0\u00b1\u00a00.2 for hormone therapy users. These changes in bone mineral density bore no relation to the hot flush status at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In recently menopausal women, hot flushes do not appear to determine bone mass density.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12546","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T14:25:24Z","timestamp":1416839124000},"page":"198-203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Postmenopausal hot flushes and bone mineral density: a longitudinal study"],"prefix":"10.1111","volume":"94","author":[{"given":"Pauliina","family":"Tuomikoski","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Helsinki University Central Hospital Helsinki 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