{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:38:02Z","timestamp":1773866282647,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,25]],"date-time":"2014-12-25T00:00:00Z","timestamp":1419465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate, develop and evaluate anatomical, surgical and anastomotic aspects necessary for a successful uterine transplant in a large\u2010animal model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Sheep model; longitudinal study involving five ewes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Royal Veterinary College, London, <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Five ewes of proven fertility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The uterine allograft along with the internal iliacs, and uterine arterial and venous tree all intact were harvested en bloc. An end\u2010to\u2010side anastomosis was performed between the external iliac vessels and the internal iliac vessels of the graft using 6\u20100 polypropylene. Successful reperfusion of the graft was initially judged by the color shift of the uterus during reperfusion. Blood flow past the venous and arterial anastomotic sites was also ensured by visual inspection, together with pulse oximetry and multispectral imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Operative details (retrieval, ischemic, clamping, reperfusion and recipient hysterectomy duration); physiological profiles; gross morphology and histopathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five autotransplants were performed. One procedure was abandoned because of the inappropriate size of sheep model. Another procedure was halted because the animal suffered from respiratory failure in the immediate intra\u2010operative period. Three transplants were completed. In those, at least two of four possible anastomoses were finished and the grafted uteri demonstrated immediate perfusion and appropriate viability 45\u00a0min post\u2010operatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Internal to external iliac vessel anastomoses are an acceptable surgical technique that should be applied in a human model to ensure adequate subsequent uterine perfusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12550","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T14:49:27Z","timestamp":1416840567000},"page":"245-252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Achieving uterine auto\u2010transplantation in a sheep model using iliac vessel anastomosis: a short\u2010term viability study"],"prefix":"10.1111","volume":"94","author":[{"given":"Srdjan","family":"Saso","sequence":"first","affiliation":[{"name":"Division of Surgery and Cancer Institute of Reproductive &amp; Developmental Biology Imperial College London Hammersmith Hospital Campus London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma","family":"Petts","sequence":"additional","affiliation":[{"name":"Department of Pathology Imperial College Healthcare NHS Trust St Mary's Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meen\u2010Yau","family":"Thum","sequence":"additional","affiliation":[{"name":"The Lister Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Corless","sequence":"additional","affiliation":[{"name":"Mid Cheshire NHS Trust Leighton Hospital Crewe UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Boyd","sequence":"additional","affiliation":[{"name":"Biological Services Unit Royal Veterinary College London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Noakes","sequence":"additional","affiliation":[{"name":"Reproduction and Obstetrics Royal Veterinary College London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Del Priore","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Southeastern Regional Medical Center Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadaf","family":"Ghaem\u2010Maghami","sequence":"additional","affiliation":[{"name":"Division of Surgery and Cancer Institute of Reproductive &amp; 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