{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T21:01:24Z","timestamp":1772830884412,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,6]],"date-time":"2015-01-06T00:00:00Z","timestamp":1420502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Finska L\u00c3\u00a4kares\u00c3\u00a4llskapet"},{"name":"P\u00c3\u00a4ivikki and Sakari Sohlberg foundation"},{"name":"Special governmental subsidy for health sciences research for Helsinki University Hospital"},{"name":"Stiftelsen Dorothea Olivia, Karl Walter och Jarl Walter Perklens minne"},{"name":"the Foundation for Pediatric Research"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>High amniotic fluid erythropoietin concentration reflects chronic fetal hypoxia. Our aim was to study amniotic fluid erythropoietin concentration in relation to neonatal outcome in pregnancies complicated by intrauterine growth restriction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Helsinki University Hospital, Finland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Sample<\/jats:title><jats:p>A total of 66 singleton pregnancies complicated by intrauterine growth restriction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Amniocentesis or amniotic fluid sampling at cesarean section was performed between 24 and 34 gestational weeks. Values of amniotic fluid erythropoietin were quantitated with immunochemiluminometric assay. Normal amniotic fluid erythropoietin was defined as &lt;3\u00a0IU\/L, intermediate as 3\u201327\u00a0IU\/L, and abnormal as &gt;27\u00a0IU\/L.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Adverse neonatal outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Abnormal biophysical profile and reversed end\u2010diastolic flow in umbilical artery were associated with abnormal amniotic fluid erythropoietin (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001 and <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.042, respectively). Abnormal amniotic fluid erythropoietin was not associated with absent end\u2010diastolic flow in umbilical artery or with oligohydramnios (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.404 and <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.080, respectively). Decreased umbilical artery <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> and base excess values were associated with abnormal amniotic fluid erythropoietin (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.027 and <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.007, respectively). Composite adverse neonatal outcome defined as intraventricular hemorrhage, periventricular leukomalacia, cerebral infarction and\/or necrotizing enterocolitis was associated with abnormal amniotic fluid erythropoietin (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High amniotic fluid erythropoietin concentrations are associated with decreased umbilical artery <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> and base excess and with adverse neonatal outcome in pregnancies complicated by intrauterine growth restriction before 34 gestational weeks. In selected pregnancies complicated by intrauterine growth restriction, determining amniotic fluid erythropoietin could be a useful additional tool in fetal surveillance and possibly in optimizing timing of delivery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12553","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T03:49:24Z","timestamp":1418096964000},"page":"288-294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Amniotic fluid erythropoietin and neonatal outcome in pregnancies complicated by intrauterine growth restriction before 34 gestational weeks"],"prefix":"10.1111","volume":"94","author":[{"given":"Laura","family":"Seikku","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Helsinki University Central Hospital Helsinki 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