{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T13:04:11Z","timestamp":1770987851249,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,25]],"date-time":"2015-01-25T00:00:00Z","timestamp":1422144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the association between orexin\u2010A level and idiopathic polyhydramnios.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Case\u2010control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary\u2010level university hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Ten term pregnant women with idiopathic polyhydramnios and, as the control group, 20 pregnant women with normal amniotic fluid levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Amniotic fluid level was measured at admission for delivery using enzyme\u2010linked immunosorbent assay. Maternal blood was obtained from a cannulated vein immediately before delivery, and umbilical blood was collected at the time of delivery, before the separation of the placenta.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Maternal and umbilical levels of orexin\u2010A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean umbilical serum orexin\u2010A level was significantly lower than maternal serum orexin\u2010A level. Umbilical serum orexin\u2010A level was positively correlated with maternal serum orexin\u2010A level, but negatively correlated with amniotic fluid index and birthweight. Umbilical serum orexin\u2010A level was lower in the idiopathic polyhydramnios group than in the control group. However, no difference in maternal serum orexin\u2010A level was observed between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Idiopathic polyhydramnios was associated with decreased umbilical serum orexin\u2010A levels. Our results provide evidence that orexin\u2010A expression may be involved in amniotic fluid regulation, causing polyhydramnios by downregulation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12559","type":"journal-article","created":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T04:01:14Z","timestamp":1418616074000},"page":"295-300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Decreased umbilical orexin\u2010A level is associated with idiopathic polyhydramnios"],"prefix":"10.1111","volume":"94","author":[{"given":"Geum Joon","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine Korea University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye\u2010Ri","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Kyung Hee University Seoul 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