{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T14:30:29Z","timestamp":1784644229761,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T00:00:00Z","timestamp":1424131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate maternal and fetal outcome in hyperemesis gravidarum comparing enteral tube feeding of the mothers with other fluid\/nutrition regimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective hospital\u2010based cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University hospital, Norway.<\/jats:p><\/jats:sec><jats:sec><jats:title>Sample<\/jats:title><jats:p>All 558 women treated for hyperemesis gravidarum 2002\u20132011; 273 received water\/electrolytes intravenously, 177 received nutritional supplements by peripheral line, 107 received enteral feeding by gastroscopically positioned nasojejunal tube and 10 received total parenteral nutrition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Different fluid\/nutritional groups were compared by chi\u2010squared or non\u2010parametric tests. The influence (odds ratio) of nutritional regimens on having small\u2010for\u2010gestational\u2010age infants was evaluated by binary logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Maternal weight gain during hospitalization and pregnancy, birthweight and gestational age at delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women receiving enteral nutrition had significantly greater weight loss on admission (median 5.0\u00a0kg) and at start of nutrition (5.5\u00a0kg) than the other treatment groups (4.0\u00a0kg) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Enteral nutrition was administered for up to 41\u00a0days (median 5\u00a0days) during hospitalization, leading to 0.8\u00a0kg weight gain (95% CI 0.5\u20131.0, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.005). The tube\u2010fed women achieved similar weight gain during pregnancy and experienced similar incidence of preterm birth or small\u2010for\u2010gestational age compared with the other treatment groups. Women with &lt;7\u00a0kg total weight gain had increased risk of birthweight &lt;2500\u00a0g and small\u2010for\u2010gestational\u2010age infants (odds ratio 3.68, 95% CI 1.89\u20137.18, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001). The nutritional regimen used was not an independent risk factor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared with other fluid\/nutrition regimens, enteral tube feeding for women affected by severe hyperemesis gravidarum is associated with adequate maternal weight gain and favorable pregnancy outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12578","type":"journal-article","created":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T08:06:36Z","timestamp":1421049996000},"page":"359-367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Hyperemesis gravidarum, nutritional treatment by nasogastric tube feeding: a 10\u2010year retrospective cohort study"],"prefix":"10.1111","volume":"94","author":[{"given":"Guro","family":"Stokke","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Haukeland University Hospital Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bente L.","family":"Gjelsvik","sequence":"additional","affiliation":[{"name":"Medical Faculty University of Bergen Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrine T.","family":"Flaatten","sequence":"additional","affiliation":[{"name":"Medical Faculty University of Troms\u00f8 Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Birkeland","sequence":"additional","affiliation":[{"name":"Medical Faculty University of Bergen Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Flaatten","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine University of Bergen Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jone","family":"Trovik","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Haukeland University Hospital Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,17]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"245","article-title":"A prospective study of nausea and vomiting during pregnancy","volume":"43","author":"Gadsby R","year":"1993","journal-title":"Br J Gen Pract"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)70349-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1003896"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2007.05.008"},{"key":"e_1_2_9_6_1","first-page":"605","article-title":"Hyperemesis gravidarum","volume":"39","author":"Hod M","year":"1994","journal-title":"A review. 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