{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T07:17:59Z","timestamp":1768634279240,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To clarify the frequency and risk factors of ovarian metastasis in women with endometrial cancer of endometrioid histology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University of the Ryukyus Japan 1990\u20132011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Eighty\u2010eight women \u226445\u00a0years of age with endometrial cancer of only endometrioid histology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinicopathological factors from the medical records were used. Fisher's exact test and logistic regression analysis were used to analyze predictive factors for ovarian metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Risk factors of ovarian malignancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All women underwent total abdominal hysterectomy, bilateral salpingo\u2010oophorectomy and lymph node dissection. The median age was 39\u00a0years, and <jats:styled-content style=\"fixed-case\">FIGO<\/jats:styled-content> stage distributions were: stage I, 63 (71.6%) women; stage <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, 14 (15.9%) women; and stage <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>, 11 (12.5%) women. Pathologically, ovarian metastasis was observed in four (4.5%) women. Only lymph node metastasis was a significant predictive factor for ovarian metastasis (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0038), and deep myometrial invasion was the only significant factor (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0085) for the prediction of lymph node metastasis. No ovarian malignancy was found in 72 women with invasion \u226450% myometrial depth and no enlargement of the ovaries. We observed ovarian metastasis in two (14.3%) of 14 women with deep myometrial invasion without ovarian tumor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ovarian preservation surgery might be considered in endometrial cancer of endometrioid histology with \u226450% myometrial depth invasion with no ovarian mass after taking into account family history.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12588","type":"journal-article","created":{"date-parts":[[2015,1,21]],"date-time":"2015-01-21T09:36:45Z","timestamp":1421833005000},"page":"430-434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Ovarian preservation in young women with endometrial cancer of endometrioid histology"],"prefix":"10.1111","volume":"94","author":[{"given":"Yoshino","family":"Kinjyo","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Graduate School of Medical Science University of 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