{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:59:57Z","timestamp":1788872397809,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T00:00:00Z","timestamp":1424995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Mermaid Project (Mermaid II)"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2015,4]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n \n Adequate follow\u2010up of women who have undergone conization for high\u2010grade cervical lesions is crucial in cervical cancer screening programs. We evaluated the performance of testing for high\u2010risk human papillomavirus (\n HPV<\/jats:styled-content>\n ) types, cytology alone, and combined testing in predicting cervical intraepithelial neoplasia grade 2 or worse (\n CIN<\/jats:styled-content>\n 2+) after conization.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Prospective cohort study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Denmark.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n 667 women attending for conization.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Cervical specimens were collected during 2002\u20132006 at first visit after conization for cytological examination and Hybrid Capture 2 detection of high\u2010risk\n HPV<\/jats:styled-content>\n . The women were passively followed until 2\u00a0years after first follow\u2010up visit by linkage to the nationwide Pathology Data Bank.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n At first visit after conization (median time, 3.4\u00a0months), 20.4% were\n HPV<\/jats:styled-content>\n \u2010positive and 17.2% had atypical squamous intraepithelial lesions or more severe cytology (\n ASCUS<\/jats:styled-content>\n +). The 2\u2010year incidence of\n CIN<\/jats:styled-content>\n 2+ after conization was 3.6%. Sensitivity for detection of\n CIN<\/jats:styled-content>\n 2+ after conization was 81.0% [95% confidence interval (\n CI<\/jats:styled-content>\n ) 58.1\u201394.6] for positive cytology (\n ASCUS<\/jats:styled-content>\n +\u00a0threshold) and 95.2% (95%\n CI<\/jats:styled-content>\n 76.2\u201399.9) for\n HPV<\/jats:styled-content>\n testing and for combined testing. Specificity of\n ASCUS<\/jats:styled-content>\n +\u00a0cytology (85.2%; 95%\n CI<\/jats:styled-content>\n 82.0\u201388.0) was higher than that of\n HPV<\/jats:styled-content>\n testing (82.4%; 95%\n CI<\/jats:styled-content>\n 79.0\u201385.4) and markedly higher than that of combined testing (73.2%; 95%\n CI<\/jats:styled-content>\n 69.3\u201376.8). The margin status had no significant added value.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Testing for high\u2010risk\n HPV<\/jats:styled-content>\n three to four months after conization is more sensitive than\n ASCUS<\/jats:styled-content>\n + cytology for identifying women at risk for relapse of\n CIN<\/jats:styled-content>\n 2+ within 2\u00a0years. Further studies are needed to evaluate whether\n HPV<\/jats:styled-content>\n testing could be a stand\u2010alone test in follow up after conization.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/aogs.12601","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T09:58:49Z","timestamp":1422871129000},"page":"405-411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Role of human papillomavirus testing and cytology in follow\u2010up after conization"],"prefix":"10.1111","volume":"94","author":[{"given":"Camilla F.","family":"Gosvig","sequence":"first","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes Danish Cancer Society Research Center Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene D.","family":"Huusom","sequence":"additional","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes Danish Cancer Society Research Center Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Deltour","sequence":"additional","affiliation":[{"name":"Section of Environment and Radiation International Agency for Research on Cancer Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus K.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Unit of Statistics, Bioinformatics and Registry Danish Cancer Society Research Center Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Katrine","family":"Duun\u2010Henriksen","sequence":"additional","affiliation":[{"name":"Unit of Statistics, Bioinformatics and Registry Danish Cancer Society Research Center Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen Merete","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Frederiksberg Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone K.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisbeth","family":"Elving","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hvidovre Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Schouenbourg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Iftner","sequence":"additional","affiliation":[{"name":"Experimental Virology Section Universitaetsklinikum Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Svare","sequence":"additional","affiliation":[{"name":"Private Gynecological Clinic Elsinore Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Iftner","sequence":"additional","affiliation":[{"name":"Experimental Virology Section Universitaetsklinikum Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne K.","family":"Kjaer","sequence":"additional","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes Danish Cancer Society Research Center Copenhagen Denmark"},{"name":"Department of Obstetrics and Gynecology Rigshospitalet Copenhagen University Hospital Copenhagen 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