{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:05:54Z","timestamp":1790690754293,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T00:00:00Z","timestamp":1425427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Conclusions on the effect of metformin on circulating anti\u2010M\u00fcllerian hormone (<jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>) levels in women with polycystic ovary syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>) are ambiguous. We performed a secondary analysis of a randomized, double\u2010blind, placebo\u2010controlled cross\u2010over trial. Fifty\u2010six women with hyperandrogenemic <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> were included. Each woman served as her own control receiving a daily dose of either 1700\u00a0mg metformin or placebo for 6\u00a0months. After a 3\u2010month wash\u2010out period they received the opposite treatment. The decrease in <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> from a median of 49.5 to 46.9\u00a0pmol\/L after 6\u00a0months on metformin was overall not significant (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.81), nor were changes in obese women (from 49.5 to 38.2\u00a0pmol\/L; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.53). Comparing individual metformin\/placebo <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> values, a small absolute decrease of 9.3\u00a0pmol\/L (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.03) was observed in obese women after 6\u00a0months relative to baseline, suggesting a trend towards decreasing values after metformin treatment, mainly in obese women.<\/jats:p>","DOI":"10.1111\/aogs.12605","type":"journal-article","created":{"date-parts":[[2015,2,7]],"date-time":"2015-02-07T13:45:01Z","timestamp":1423316701000},"page":"547-551","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Impact of metformin on anti\u2010M\u00fcllerian hormone in women with polycystic ovary syndrome: a secondary analysis of a randomized controlled trial"],"prefix":"10.1111","volume":"94","author":[{"given":"Helen N.","family":"Madsen","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry Aarhus University Hospital Skejby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn F.","family":"Lauszus","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Herning Hospital Herning Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitta","family":"Trolle","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aarhus University Hospital Skejby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans J.","family":"Ingerslev","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aarhus University Hospital Skejby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"T\u00f8rring","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Aarhus University Hospital Skejby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61345-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1582"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030727"},{"key":"e_1_2_7_5_1","first-page":"CD003053","article-title":"Insulin\u2010sensitising drugs (metformin, rosiglitazone, pioglitazone, d\u2010chiro\u2010inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility","volume":"5","author":"Tang T","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0733"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep074"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2012.736563"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2010.507283"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1725"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.05.098"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh850"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem271"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faogs.12605","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.12605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:30:04Z","timestamp":1695544204000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.12605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,4]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/aogs.12605"],"URL":"https:\/\/doi.org\/10.1111\/aogs.12605","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,4]]},"assertion":[{"value":"2014-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-01-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-03-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}